脂毒性在非酒精性脂肪性肝炎中的作用机制

郅果果; 穆杰; 邵冰杰; 王东

doi:10.3969/j.issn.1001-5256.2023.07.024

脂毒性在非酒精性脂肪性肝炎中的作用机制

DOI: 10.3969/j.issn.1001-5256.2023.07.024

成都中医药大学基础医学院，成都 611137

基金项目:

国家自然科学基金 (82104655)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：郅果果负责撰写论文；穆杰、邵冰杰负责查阅，归纳文献；王东负责指导撰写，修改论文。

详细信息

通信作者:
王东，wangdong@cdutcm.edu.cn (ORCID: 0000-0002-6387-9169)

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出版历程
- 收稿日期: 2022-10-22
- 录用日期: 2022-11-29
- 出版日期: 2023-07-20

Mechanism of action of lipotoxicity in nonalcoholic steatohepatitis

School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

Research funding:

National Natural Science Foundation of China (82104655)

More Information

Corresponding author: WANG Dong, wangdong@cdutcm.edu.cn (ORCID: 0000-0002-6387-9169)

摘要

摘要: 非酒精性脂肪性肝炎(NASH)作为非酒精性脂肪性肝病(NAFLD)病情加剧的重要环节, 炎症和肝损伤是该阶段的重要病理学特征。脂毒性作为NASH的致病机制之一, 能够通过多种途径调控肝脏的炎症和肝细胞凋亡。本文从炎症和肝细胞凋亡两个层面重点阐述脂毒性对NASH的具体调控机制, 其中涉及了多种肝脏非实质细胞和JNK、NF-κB、caspase介导的细胞凋亡等信号通路, 为临床NASH的诊断和治疗提供了新思路。
- 非酒精性脂肪肝炎 /
- 脂毒性 /
- 炎症 /
- 细胞凋亡
Abstract: Nonalcoholic steatohepatitis (NASH) is an important part of the exacerbation of nonalcoholic fatty liver disease (NAFLD), and inflammation and liver damage are important pathological features of this stage. As one of the pathogenic mechanisms of NASH, lipotoxicity can regulate liver inflammation and hepatocyte apoptosis through multiple pathways. Therefore, this article elaborates on the specific regulatory mechanism of lipotoxicity on NASH from the two aspects of inflammation and hepatocyte apoptosis, which involves a variety of liver nonparenchymal cells and various signaling pathways such as JNK, NF-κB, and caspase-mediated cell apoptosis, so as to provide new ideas for the diagnosis and treatment of NASH in clinical practice.
- Nonalcoholic Steatohepatitis /
- Lipotoxicity /
- Inflammation /
- Apoptosis

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参考文献(38)

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