脂多糖在肝癌发生发展中的作用

王涛; 王权; 宋立华; 段学章

doi:10.3969/j.issn.1001-5256.2023.07.032

脂多糖在肝癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2023.07.032

王涛¹,
王权¹,
宋立华²,
段学章^1, , ,

1.
中国人民解放军总医院第五医学中心肿瘤医学部，北京 100039
2.
北京化工大学生命科学与技术学院，北京 100089

基金项目:

国家自然科学基金青年项目 (82003211)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：王涛负责收集数据，撰写论文；王权负责资料整理；宋立华负责修改论文；段学章指导撰写文章，提供写作思路，修改文章并最终定稿。

详细信息

通信作者:
段学章，duanxuezhang2006@163.com (ORCID: 0000-0002-1941-9317)

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- 被引次数: 0
出版历程
- 收稿日期: 2022-10-11
- 录用日期: 2022-11-14
- 出版日期: 2023-07-20

Role of lipopolysaccharide in the development and progression of liver cancer

1.
Department of Medical Oncology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
2.
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100089, China

Research funding:

Youth Program of National Natural Science Foundation of China (82003211)

More Information

Corresponding author: DUAN Xuezhang, duanxuezhang2006@163.com (ORCID: 0000-0002-1941-9317)

摘要

摘要: 肝癌是世界范围重大的公共卫生疾病。近来随着高通量测序及基因编辑技术的进步，肠道微生物群通过“肝-肠轴”途径在肝癌发生、进展及转移过程中的生物学机制被进一步揭示，特别是发现革兰阴性细菌外膜脂多糖可动员下游一系列致癌相关免疫级联反应。本文从肠道环境改变与肝癌发生的关系、脂多糖免疫调控、临床前治疗研究等方面，对肠道微生物脂多糖在肝癌发生发展中的可能作用机制进行了综述。
- 肝肿瘤 /
- 胃肠道微生物组 /
- 脂多糖类 /
- 细菌
Abstract: Liver cancer is an important public health issue worldwide. With the improvements in high-throughput sequencing and gene editing techniques in recent years, studies have further revealed the biological mechanism of intestinal microflora in the development, progression, and metastasis of liver cancer via the gut-liver axis, and in particular, it has been found that lipopolysaccharide, a component of the outer membrane of gram-negative bacteria, can cause downstream immune cascade reactions. This article reviews the possible mechanism of action of intestinal microflora lipopolysaccharide in the development and progression of liver cancer from the aspects of the association between intestinal environmental changes and liver cancer, immunoregulation by lipopolysaccharide, and preclinical treatment.
- Liver Neoplasms /
- Gastrointestinal Microbiome /
- Lipopolysaccharides /
- Bacteria

HTML全文

图 1 肠道微生物LPS致癌机制

Figure 1. Mechanism of the gut microbiota lipopolysaccharide in hepatocarcinogenesis

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