胆汁淤积性肝病动物模型构建的研究进展

张清清; 曲颖; 蔡晓波; 陆伦根

doi:10.3969/j.issn.1001-5256.2023.07.035

胆汁淤积性肝病动物模型构建的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.07.035

上海交通大学医学院附属第一人民医院消化科，上海 200080

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张清清负责资料分析，查阅文献，撰写论文；曲颖、蔡晓波负责修改论文；陆伦根负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
陆伦根，lungenlu1965@163.com (ORCID：0000-0002-1533-4068)

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出版历程
- 收稿日期: 2022-10-13
- 录用日期: 2023-01-13
- 出版日期: 2023-07-20

Research advances in animal models of cholestatic liver disease

Department of Gastroenterology, The First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China

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Corresponding author: LU Lungen, lungenlu1965@163.com (ORCID: 0000-0002-1533-4068)

摘要

摘要: 胆汁淤积性肝病(CLD)是一类由免疫、遗传、环境等因素导致胆汁流动障碍，从而造成胆汁酸在肝脏和/或循环中的淤积的疾病。CLD发病机制尚未完全明确，且治疗困难，动物模型作为人类疾病的替代对象，可以为探索疾病的病因病理及寻找合适的治疗靶点提供平台，本文就目前CLD动物模型的研究进展作一综述。
- 肝疾病 /
- 胆汁淤积 /
- 疾病模型，动物
Abstract: Cholestatic liver diseases (CLD) are a series of diseases due to impaired bile flow and accumulation of bile acid in the liver and/or systemic circulation caused by immune, genetic, and environmental factors. The pathogenesis of CLD remains unclear and CLD is difficult to treat. As a substitute for human diseases, animal models can provide a platform for exploring the etiology and pathogenesis of the disease and finding appropriate therapeutic targets. This article reviews the current research advances in the animal models of CLD.
- Liver Diseases /
- Cholestasis /
- Disease Models, Animal

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