PDF下载 ( 1148 KB)
Clinical study of the role of glutamine in immunological function during postoperative obstructive jaundice
-
摘要:
目的探讨谷氨酰胺对梗阻性黄疸免疫功能的影响。方法收集48例良性梗阻性黄疸患者的临床资料,并对患者血清的内毒素（ET）、可溶性白细胞介素2受体（sIL-2R）、T淋巴细胞亚群、免疫球蛋白等进行检验。结果谷氨酰胺干预组和梗阻性黄疸对照组相比,谷氨酰胺干预组血清中的sIL-2R较梗阻性黄疸对照组下降明显;两组T淋巴细胞亚群、免疫球蛋白、ET和sIL-2R水平的变化差异具有统计学意义。结论谷氨酰胺对良性梗阻性黄疸术后的免疫功能变化具有一定的影响。
Abstract:Objective To investigate the influence of glutamine on immune function in patients with postoperative obstructive jaundice.Methods Clinical data and serum was collected from 48 patients who experienced obstructive jaundice following general surgery.Twenty-four of the patients were assigned to the glutamine intervention group.The levels of endotoxin, soluble interleukin-2 receptor (sIL-2R) , T lymphocyte subgroups, and immunoglobulins were measured and compared between the untreated control and glutamine-treated groups.Results The serum levels of endotoxin and SIL-2R were significantly lower in glutamine-treated patients than in the untreated controls.The levels of T lymphocyte subgroups and immunoglobulins variably increased and decreased during the glutamine treatment period, but were consistently significantly different from the levels in the untreated control group.Conclusion Postoperative treatment with glutamine can modulate levels of immunological factors, and presumably immune function, in patients with obstructive jaundice.
-
Key words:
- jaundice /
- obstructive /
- glutamine /
- antibody formation
-
[1]黎介寿, 吴孟超, 黄志强.普通外科手术学[M].第2版.北京:人民军医出版社, 2005:663-664. [2]Ljungdahl M, Osterberg J, Ransj U, et al.Infammatory re-sponse in patients with malignant obstructive jaundice[J].Scand J Gastroenterol, 2007, 42 (1) :94-102. [3]Kimmings AN, van Deventer SJ, Obertop H, et al.Endotox-in, cytokines, and endotoxin binding proteins in obstructivejaundice and after preoperative biliary drainage[J].Gut, 2000, 46 (5) :725-731. [4]Yuceyar H, Kokuluday A, Coker A, et al.The serum levels of solu-able interlukin-2 receptor levels in patients with obstructive jaun-dice[J].Hepatogastroenterology, 1996, 43 (10) :949-954. [5]Larson SD, Li J, Chung DH, et al.Molecular mechanismscontributing to glutamine-mediated intestinal cell survival[J].Am J Physiol Gastrointest Liver Physiol, 2007, 293 (6) :G1262-1271. [6]Zulfikaroglu B, Ozmen MM, Ozalp N, et al.The effect of im-munonutrition on bacterial translocation, and intestinal villusatrophy in experimental obstructive jaundice[J].Clin Nutr, 2003, 22 (3) :277. [7]Kuru B, Dinc S, Altinok G, et al.Effect of different enteralnutrients on bacterial transl ocation in experimental obstruc-tive jaundice[J].Eur Surg Res, 2004, 36 (1) :45-52. [8]Mondello S, Italiano D, Giacobbe MS, et al.Glutamine-sup-plemented total parenteral nutrition improves immunological sta-tus in anorectic patients[J].Nutrition, 2010, 26 (6) :677-681. [9]Rogero MM, Borelli P, Vinolo MA, et al.Dietary glutaminesupplementation affects macrophage function, hematopoie-sis and nutritional status in early weaned mice[J].Clin Nutr, 2008, 27 (3) :386-397. [10]Sheen-Chen SM, Eng HL, Hung KS, et al.Altered serumtransforming growth factor-beta1 and monocyte chemoat-tractant protein-1 levels in obstructive jaundice[J].World JSurg, 2004, 28 (10) :967-970. [11]Fumarola C, La Monica S, Guidotti GG.Amino acid signalingthrough the mammalian target of rapamycin (mTOR) path-way:Role of glutamine and of cell shrinkage[J].J CellPhysiol, 2005, 204 (1) :155-165. [12]Amino Marc Rhoads J, Wu G.Glutamine, arginine, andleucine signaling in the intestine[J].Amino Acids, 2009, 37 (1) :111-122. [13]Margaritis VG, Filos KS, Michalaki MA, et al.Effect of oral glu-tamine administration on bacterial tanslocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructivejaundice[J].World J Surg, 2005, 29 (10) :1329-1334. [14]宫路路, 韩喜春, 姜伟栋.谷氨酰胺对梗阻性黄疸大鼠可溶性白细胞介素2受体的影响[J].中国普外基础与临床, 2006, 13 (4) :445-446. -
下载:
