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The Targets Hyperfibrinolysis Influence the Prognosis in Cirrhosis Patients
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摘要: 为观察肝硬化患者外周血纤溶功能变化。分别用发色底物法、酶联免疫吸附法测定 6 8例肝硬化 ,37例正常人外周血的组织型纤溶酶原激活物活性 （t PA :A）及其抗原 （t -PA :Ag） ,纤溶酶原激活物抑制物活性 （PAI-A）及D -二聚体。结果显示 :肝硬化患者纤溶指标t -PA :A、t -PA :Ag及D -二聚体显著高于正常人 ,失代偿者明显高于代偿者。而PAI-A变化与其相反。提示 :肝硬化患者外周血存在不同程度的纤溶活性增高 ,测定上述指标对估计肝功能及临床用药有指导意义。Abstract: WT5”BZ] To investigate the function of fibrinolysis in patients with cirrhosis, Plasminogen activator inhibitor-A (PAI-A) 、tissue-type plasminogen activator-A (t-PA:A) and t-PA:Ag were assayed by chromogenic assay, D-dimer was assayed by ELISA.These targets were assayed in 37 healthy volunteers and 68 patients with cirrhosis (36 in compensatory stage and 32 in incompensatory stage) .Results:t-PA:A、t-PA:Ag and D-dimer in serum concentration were significant higher in cirrhosis group than healthy volunteers group, they were also significant higher in incompensatory cirrhosis group than compensatory cirrhosis group, PAI-A was by contrary in incompensotory cirrhosis group, compensatory cirrhosis group and healthy volunteers group. Conclusions:Hyperfibrinolysis is signifirance in cirrhosis patients in different degree. [WT5”HZ]
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Key words:
- Cirrhosis fibrinolysis /
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