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Study on fibrinogen bound sialic acid levels in the patients with liver cirrhosis
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摘要: 应用饱和硫酸铵制备纯化纤维蛋白原 ,硫代巴妥酸法测定了肝硬化患者纤维蛋白原结合唾液酸(FSA)的水平 ,结果显示病人的纤维蛋白原结合唾液酸水平 2 3.6± 2 .6nmul/mg ,显著高于正常对照组 18.4± 3.7mol/mg(P <0 .0 1) ,并且凝血酶时间的延长与FSA的升高呈高度正相关 (P <0 .0 1) ;纤维蛋白单体聚合的速度与纤维蛋白原结合唾液酸成反比。表明纤维蛋白原结合唾液酸的水平可作为诊断肝硬化获得性异常纤维蛋白血症的理想指标。Abstract: Fibrinogen was purified by precipitation from citrated plasma by saturated ammonium sulplvate.Fibrinogen bound sialic acid levels were determined in 26 patients with liver cirrhosis and 22 normal cotrols.The result of the patients with liver cirrhosis was (23.6±2.6) nmol/mg.The result of the controls was 18.4±3.7 nmol/mg.The level of the patients was significantly higher than that of the controls (P<0.01) .In addition there was relationship between prolongation of the thrombin time and fibrinogen bound sialic acid contents.Polymerization of fibrin monomer was inverse ratio with fibrinogen bound sialic acid.It suggests that fibrinogen boud sialic acid levels may be diagnostic index acquired dysfibrinogenaemia.
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