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Relationship between tumor necrosis factor-α and lnsulin resistance in patients with liver cirrhosis
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摘要: 为探讨肝硬化患者血清肿瘤坏死因子 -α（TNF -α）水平变化及与胰岛素抵抗 （IR）的关系。采用氧化酶法、放免法和酶联免疫法分别测定 2 3例肝硬化患者 （A组 ）、2 1例健康人 （B组 ）的空腹血糖 （FBG）、空腹胰岛素（FINS）及血清TNF -α值 ,并计算胰岛素敏感指数 （ISI）。A组FINS、TNF -α水平较B组显著增高 ,而ISI较B组显著降低。相关分析发现 ,TNF -α与ISI呈显著负相关 ,而与FINS呈显著正相关。肝硬化患者TNF -α水平增高 ,导致胰岛素抵抗产生 ,可能是肝硬化患者糖代谢紊乱的重要原因之一。Abstract: To investigate the changes of tumor necrosis factor-α (TNF-α) with liver cirrhosis and the relationship between TNF-α and insulin resistance (IR) , 23 liver cirrhosis (groupA) ; 21 health without liver cirrhosis (groupB) were selected to compare fasting blood-glucose (FBG) , fasting blood-insulin (FINS) and serum TNF-α by oxidase method, RIA and ELISA, Insulin sensitivity index (ISI) was also calculated. Analysis of variance revealed that FINS, TNF-α were significantly higher while ISI lover in group A than those in group B. Correlation analysis showed that TNF-α was negatively correlated to ISI, and positively associated with TNF-α and FINS. The study indicates that significantly hight level of TNF-α and IR play an important role in the liver cirrhosis and glucose metabolic disorder.
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Key words:
- liver cirrhosis /
- tumor necrosis factor-α /
- insulin resistance
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