Abstract: To evaluate the effect of PVI on refractory hepatogenous pleural effusion due to cirrhosis, 412 casses with cirrhosis treated in our hospital during the last 4 years were collected.After the rountine therapy, refractory hepatogenous pleural effusion of right cavity developed in 21 cases and PVI were injected into right pleural cavity of them (4ml at 1 st?2 nd time, 6ml at 3 rd?4 th time;8ml at 5 th time) .The quantity of pleural effusion were monitored in the treating course.The pleural effusion disappeared in 12 cases, 7 cases remaind some the pleural effusion and had to be encapsulated and effusion in 2 cases did not decreased.The total therapeutic efficacy rate was 90.5%.The times of PVI injection were 2.71±0.58 in patients with infectous effusion, 3.65±0.77 in those with transudatory dropsy and 5.5 times in those with chylous effusion.The result indicated that PVI can be a first measure for the patients with refractory pleural effusion due to cirrhosis.