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Relationship between serum leptin and liver fibrosis in patients with alcoholic liver disease
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摘要: 研究瘦素与酒精性肝病 （ALD）肝纤维化发生发展的关系。用ELISA法检测 6 0例ALD患者血清瘦素水平 ,16例健康人作为对照组 ,同步检测了ALD患者的血清肝纤维化指标HA、LN、PC -Ⅲ及TGFβ1,对血清瘦素与肝纤维化指标、肝组织纤维化分期间的关系进行了分析。ALD患者的血清瘦素水平明显高于对照组 ,在单纯性脂肪肝 （AFL）、脂肪性肝炎 （AH）、脂肪性肝硬化 （ALC）瘦素水平依次增高 ,差异有显著性。在AH、ALC血清瘦素水平与肝纤维化血清学指标和TGFβ1正相关 ,ALD患者的血清瘦素水平与肝组织纤维化分期密切相关。血清瘦素是ALD患者肝纤维化的始动因子之一Abstract: To study the role of leptin in liver fibrosis formation in ALD patients. Serum leptin was detected by ELISA in 60 patients with ALD (Alcoholic fatty liver AFL n=14, Alcoholic hepatitis AH n=28, Alcoholic cirrhosis ALC n=18) . 16 healthy persons serves as normal control (NC) . Serum liver fibrosis markers (HA, LN, PCⅢ) and TGF β 1 were determined at the same time. we observed: 1) Serum leptin levels in patients with ALD were higher than that in NC (P<0.05/0.01) and increased successively in AFL, AH, ALC. 2) Serum leptin was correlated with serum levels of HA, LN, PCⅢ and TGFβ 1 positively (P<0.05/0.01) in patients with AH and ALC, also serum leptin levels were related remarkably with the liver fibrosis stage. The results indicated that Leptin is as one crucial profibrogenic factor in the fibrosis formation of ALD patients.
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Key words:
- leptin /
- hepatic fibrosis /
- alcoholic liver disease
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[1] CaroJF , SinhaMK , KolaczynskiJW , etal.Leptin:thetaleofanobesi tygene[J].Diabetes, 1996, 45 (11) ∶1455-62. [2] KimuraK , TsudaK , BabaA , etal.Invdvementofnitricoxideinen dothelium-dependentarterialrelaxationbyleptin[J].BiochemBiophysResCommun, 2000, 273 (2) ∶745-9. [3] PotterJJ, WomackL , MezeyE , etal.Transdifferentiationrathepaticstellatecellsresultsinleptinexpression[J].BiochemBiophysResCom mun.1998, 244 (1) ∶178-82. [4]中华医学会.酒精性肝病诊断标准[J].中华肝脏病杂志, 2003, 11 (2) ∶72. [5]王泰龄, 赵静波, 张道明, 等.酒精性肝病[M].北京:中国医药科技出版社, 2001∶25-39. [6] IkejimaK , HondaH , HiroseM , etal.Asaprofibrogenicfactorintheliver[J].Gastroenterology, 2000, 118∶A1014. [7] IkejimaK , HondaH , YoshikawaM , etal.Leptinaugmentsinflammato ryandprofibrogenicresponsesinthemurineliverinducedbyhepatotoxicchemicals[J].Hepatology, 2001, 34 (2) ∶288-97. -
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