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Influence to serum endotoxin and TNF-α in cirrhosis patients with beifeida therapy
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摘要: 探讨新一代微生态制剂贝飞达对肝硬化患者血浆内毒素及TNF -α的影响。对92例肝硬化患者随机分成治疗组和对照组,并分别服用贝飞达和培非康共三周,采用偶氮显色法检测血浆内毒素,酶联免疫吸附法测定血浆TNF -α水平。①两组患者治疗后血浆内毒素及TNF -α水平均有下降。②治疗组与对照组比较,血浆内毒素及TNF -α水平下降更明显,有统计学意义（P <0 .0 5 ）。活菌制剂贝飞达疗效优于培非康,肝硬化患者在临床治疗时宜尽量采用活菌制剂。Abstract: To discuss Influence to seru m endotoxin and TNF-α in cirrhosis patients with beifeida therapy.92 patients w ith cirrhosis were enrolled in present study and divided into treated and contro l group and treated by beifeida and peifeikang separately.Serum endotoxin was de termined by azo-matrix color reaction;and TNF-α by ELISA.①The level of serum e ndotoxin and TNF-α were descended in two groups.②The level of serum endotoxin and TNF-α was descended greatly compared to control group.The curative effect o f beifeida was excel to peifeikang and should use alive bacterium preparation in therapy of cirrhosis patients as faras posible.
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[1]中华医学会病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19 (1) ∶56 [2]WiloreDW .Theguit;acentralorganaftersurgicalstress[J].Surgery, 1998, 104∶917. [3] DeitchEA .Bacterialtranslocationofthegutflora[J].JTrauma, 1990, 30 ( (12) ;sl184. [4] MadausMA .EffectofTcellmodulationonthetranlocationofbacteriafromthegutandmesentericlempynode[J].AnnSurg, 1998, 207∶387. -
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