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Monitoring the change of interleukin-6 in the alcoholic liver disease and its clinical significance
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摘要: 探讨酒精性肝病患者IL - 6的活性改变与酒精性肝病肝纤维化的临床意义。测定了12 0例酒精性肝病患者和30例健康成年人（对照组）的IL - 6、HA、LN、PC -Ⅲ、Ⅳ-C。酒精性肝病患者,血清IL - 6明显高于对照组,有显著性差异（P <0 .0 5～0. 0 1）。酒精性肝病患者血清中HA、LN、PC -Ⅲ、Ⅳ-C的改变明显高于对照组（P <0. 0 1～0 .0 0 1）。IL - 6的活性改变与酒精性肝病的肝纤维化呈正相关性。Abstract: To study the relationship be tween the change of interleukin-6 (IL-6) activity and the level of hepatic fibro sis in alcoholic liver disease (ALD) .Among the 120 patients with ALD, the level o f interleukin-6 (IL-6) ?hyaluronic acid (HA) ?laminin (LN) , type Ⅲ procollagen ( PC-Ⅲ) and type Ⅳ collagen (Ⅳ-C) in serum is monitored.The same items are moni tored in the control group with 30 healthy people.The in acase of IL-6 in ALD gr oup (P<0.05～0.001) .The changes of HLIV?PC-Ⅲ and Ⅳ is marked nigher than the control group (P<0.001～0.0001) .The changes of IL-6 activity is Posilive correlaled with the level of hepatic fibrosis in ALD.
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Key words:
- alcoholic liver disease /
- in terleukin-6 /
- hepatic fibrosis
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[1]梁扩寰肝脏病学[M].北京∶人民卫生出版社, 1995∶738 [2]森本道雄酒精性肝损害的最新研究进展[J].日本医学介绍, 1997, 72∶83 [3] GreventP , IraburuMJ, ReyesRoneroM , etat.Inductionofanaccutephaseinratsstimulatestheexperssionofal (I) porcollagenmessengerri bonucleicacidintheirlivers[J].LabInvest, 1995, 72∶83. -
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