血清ALD和sE-Cad检测在TAE治疗原发性肝癌中的意义

劳明; 欧盛秋; 吴芸; 潘元平; 朱波; 黄文成

血清ALD和sE-Cad检测在TAE治疗原发性肝癌中的意义

1. 广西医科大学附属肿瘤医院
2. 广西中医学院第一附院

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中图分类号: R735.7
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出版历程
- 出版日期: 2007-02-20

The significance of the measurement of fructose 1, 6-disphosphate aldolase and soluble E-cadherin in transcatheter arterial embolization for hepatocellualcarcinoma

摘要

摘要: 为探讨血清1,6-二磷酸果糖醛缩酶（ALD）和可溶性上皮型钙粘蛋白（sE-Cad）检测对行经皮肝动脉灌注化疗栓塞术（TAE）治疗原发性肝癌疗效的临床价值,对46例原发性肝癌行TAE术后监测各阶段患者血清ALD、sE-Cad及甲胎蛋白（AFP）的变化并进行比较,结果显示,ALD活性变化反映了肝癌组织的坏死程度,sE-Cad及AFP水平随治疗进行呈下降趋势,ALD活性及sE-Cad水平术前、术后比较均有显著性差异P<0.05,血清ALD活性及sE-Cad水平检测均可用于TAE治疗原发性肝癌的疗效评价,特别是对AFP阴性的肝癌患者的疗效判断有较大的临床应用价值。
- 1,6-二磷酸果糖醛缩酶 /
- 可溶性上皮钙粘蛋白 /
- 原发性肝癌 /
- 经皮肝动脉灌注化疗栓塞术
Abstract: To evaluate the value of fructose 1, 6-Diphosphate Aldolase (ALD) and Soluble ECadherin (sE-Cad) on treating hepatocellular carcinoma (HCC) by transcatheter atterical Embolization (TAE) .There are 46 patients treated with TAE.The changes of serum levels of ALD and sE-Cad were analyzed in different stages after TAE.And the levels of the serum alpha-fetoprotein (AFP) were also analyzed.The results showed that the changes in serum levels of ALD indicated necrosis degree of tumor tissue in HCC.And the levels of sE-Cad and AFP in serum were reduced with developing of treatment.The levels of ALD and sE-Cad in serum there were obvious differentia after TAE treatment than before that (P<0.05) .Levels of ALD and sE-Cad in serum after TAE treatment were clinically useful to evaluate HCC, especially for the patients with low AFP.
- fructose 1 /
- 6-diphosphate aldolase /
- soluble E-cadherin /
- hepatocellular carcinoma

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参考文献(8)

[1]王建华, 王小林, 颜志平.腹部介入放射学[M].上海:上海医科大学出版社, 1998∶55-69.

[2] 安锋, 王平基, 韩国宏.经肝动脉灌注和化疗灌注栓塞治疗中晚期肝癌的临床分析[J].中国腹部疾病杂志, 2001, 1 (6) ∶499-500.

[3]Chen M, Li J, Zhang Y.et al.Transarterial chemoembolization withhigh dose iodized oil for the treatment of large hepatocellular carcino-ma[J].Chin J Oncol, 2001, 23 (4) ∶165-167.

[4]Khan K N, Yatsuhashi H, Yamasaky K, et al.Prospective anylysisof risk actoes for early intahepatic recurrence of hepatocellular carci-noma following ethanol injection[J].J Hepatolog, 2000, 32 (2) ∶269-278.

[5]李航, 黎乐群.细针肝穿活检对原发性肝癌的诊断价值及针道种植预防[J].中华肝脏病杂志, 2000, 8 (5) ∶271.

[6] 张天泽, 徐光炜.肿瘤学[M].天津:天津科学技术出版社, 1997∶1556-1558.

[7]李航, 黎乐群, 万里凯, 等.1, 6-二磷酸果糖醛缩酶对无水酒精注射治疗原发性肝癌中的观察[J].中国肿瘤临床, 2004, 31 (6) ∶309-311.

[8]Katayama M, Hirai S, Kamihagi K, et al.Soluble E-cadherin frag-ments increased in circulation of cancer patients[J].Br J Cancer, 1994, 69∶580-585.

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