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Observation of terlipressin with retention-enema of traditional Chinese drug in management of patients with hepatorenal syndrome
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摘要: 目的观察特利加压素联合中药泻心汤保留灌肠治疗肝硬化失代偿期肝肾综合征的疗效。方法26例患者分为二组,在综合治疗的基础上,对照组使用多巴胺联合大剂量速尿,治疗组使用特利加压素联合中药泻心汤保留灌肠。治疗期间观察患者的临床症状、尿量、尿素氮、血肌酐、肝功能、血氨、腹水的消长及治疗后转归情况。结果治疗组尿量显著增加,尿素氮、血肌酐降低,肝功能有不同程度好转、血氨下降,而对照组无明显改善,二组比较差异显著。结论特利加压素可改善血流动力学变化,联合中药灌肠清除内毒素减少内源性血管活性物质的激活,可增加疗效,有助于肝功能的恢复。Abstract: Objective To observe the effect of terlipressin with retention-enema of traditional Chinese drug-xiexin docoction in management of patients with hepatorenal syndrome.Methods 26 patients were divided into two groups, terlipressin with retention-enema of traditional Chinese drug-xiexin decoction were used in the treating group, while in the control group the dopamine and large-dose of lasix were administered.The clinical symptoms, total urine output, serum creatinine, BUN, liver function and ascites were observed during treatment.Results In the treating group, the total urine output was increased significantly;the serum creatinine、BUN and blood amonia were descended;the liver function was better than before.However there weren't obviously improvement in the control group.Conclusion Because the hemodynamics were changed by the terlipressin and the endotoxin was reduced by retention-enema of traditional Chinese drug, terlipressin with retention-enema of traditional Chinese drug-xiexin docoction can get enhanced results.
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Key words:
- hepatorenal syndrome /
- terlipressin /
- traditional chinese drug /
- liver cirrhosis
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[1]Gines A, Ecorsell A, Gines P, et al.Incidence, predicitive factorsand prognosis of the hepatorenal syndrome in cirrhosis withascites[J].Gastroenterology, 1993, 105 (1) ∶229-230. [2]孙静媛, 兰孟冬.内毒素对肝硬化及重型肝炎各种并发症和预后的影响[J].河北医学, 2001, 7 (10) ∶878-880. [3]Arroyo V, Gines P, Gerbes A, et al.Definition and diagnostic crite-ria of refractory ascites and hepatorenal syndrome in cirhosis.Interna-tional Ascites clubs[J].Hepatology, 1996, 23 (1) ∶164-173. [4]Schrier RW, Arroyo V, Bermardi M, et al.Pcriphcral artcrial vaso-dilatation hypothesis:a proposal for the initiation of renal sldium andwater retention on cirrhosis[J].Hepatology, 1998, 8 (5) ∶1151-1157. [5] 梁扩寰, 李绍白.肝脏病学[M].第二版.北京:人民卫生出版社, 2006∶522-524, 541-557. [6]孙波, 慎睿哲, 关云林, 等.血管活性药物治疗肝肾综合征[J].胃肠病学, 2005, 10 (2) ∶127-128. [7]熊玉霞, 孟宪丽, 张艺, 等.泻心汤及其拆方抗内毒素作用研究[J].中药药理与临床, 2007, 23 (1) ∶7-8. [8]武希润, 郭文栋, 马学惠, 等.大黄对暴发性肝衰竭肝损伤及肝再生的影响[J].中华肝脏, 1999, 7 (3) ∶179. [9]何冬宁, 徐锡坤, 许娟华, 等.牡蛎提取营养液对大剂量CCl4致小鼠急性肝损伤的保护作用[J].中国公共卫生学报, 1997, 16 (3) ∶152-153. [10]嵇扬, 靳守东, 刘云, 等.牡蛎水提取液对小鼠腹腔巨噬细胞释放一氧化氮的影响[J].中医药学报, 2001, 29 (3) ∶62-63. -
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