Abstract: Objective To explore the effect of Salvia injection on lipid mechanism and tumor necrosis factor α (TNF-α) in the nonalcohic fatty liver of rats.Methods To produce a fatty liver model, a fat-rich diet, consisting of 8% lard oil+4%cholestrol, was given to male Sprague-Dawley rats for 8 weeks.The normal control rats were fed normal diets.Malondialdehyde (MDA) , superoxide dismutase (SOD) in blood serum and haptic tissue were tested.the expression of TNF-α in blood serum was also tested in RIA.Pathologic changes in rats liver were observed during experiments, Salvia injection was treated through abdominal cavity.Results The level of MDA in blood surum and liver tissues were higher than nomal group (P<0.01, P<0.05 respectively) , contrasted with Salvia injection group (P<0.05) .The level of SOD in blood serum was lower than nomal group (P<0.05) .The expression of TNF-α was lower than normal group (P<0.05) .The fat area in liver of model group was biger and more serious than nomal group (P<0.001) , contrasted with Salvia injection (P<0.05) .Pericellular fibrosis was founded in fatty liver rats.Conclusion Salvia injection could reduce lipid level, improve lipid oxide and resist fat reserve.