结缔组织生长因子与肝脏纤维化

谢永鹏; 臧秀贤; 吴扬; 李迎今; 张楠

结缔组织生长因子与肝脏纤维化

吉林大学第一医院急诊科

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2011-01-20

The relationship between connective tissue growth factor and hepatic fibrosis

摘要

摘要: 结缔组织生长因子(CTGF)具有促成纤维细胞增殖、胶原及细胞外基质合成等作用,是一种促器官纤维化的重要细胞因子。CTGF与肝纤维化的发生密切相关,在人肝纤维化、肝硬化及实验性肝纤维化模型中CTGF的表达显著增加,而抑制肝细胞CTGF的表达可显著减少胶原等细胞外基质的表达,有效的阻抑肝纤维化的进程。有关CTGF的进一步研究将对于揭示肝纤维化及肝硬化发病和治疗机理以及临床诊治等具有重要的意义。本文对CTGF的功能及其在肝纤维化形成、诊断和治疗中作用进行了综述和讨论。
- 胞间信号肽类和蛋白质类 /
- 即早蛋白质类 /
- 肝硬化
Abstract: The connective tissue growth factor (CTGF) can enhance the proliferation of fibroblasts and promote the extra cellular matrix synthesis.It is an important cytokine that can promote organ fibrosis.There is a strong correlation between the CTGF and hepatic fibrosis.The CTGF expression of human hepatic fibrosis, cirrhosis and experimental hepatic fibrosis model is significantly rising.The inhibition of CTGF expression can reduce the extra cellular matrix synthesis, resulting in the inhibition of hepatic fibrosis.The further study of CTGF is important for the pathogenesis, therapeutic mechanism and the clinical treatment of hepatic fibrosis and cirrhosis.In the review, the function of CTGF and its state on the pathogenic process, diagnosis and treatment of hepatic fibrosis were summarized and discussed.
- intercellular signaling peptides and proteins /
- immediate-early proteins /
- liver cirrhosis

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参考文献(25)

[1]Brigstock DR.The CCN family:a new stimulus pack-age[J].Endocrinol, 2003, 178 (2) :169-175.

[2]Bradham DM, Igarashi A, Potter RL, et al.Connective tissue growth factor:a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10[J].Cell Biol, 1991, 114 (6) :1285-1294.

[3]Leask A, Abraham DJ.The role of Connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology[J].Biochem Cell Biol, 2003, 81 (6) :353-363.

[4]Lasky JA, Ortiz LA, Tonthat B, et al.Connective tissues growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis[J].Am J Physiol, 1998, 275 (2pt1) :365-371.

[5]Igarashi A, Nashiro K, Kikuchi K.Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders[J].Invest Dermatol, 2004, 106 (4) :729-735.

[6]Cicha I, Goppelt-Struebe M.Connective tissue growth factor:context-dependent functions and mechanisms of regulation[J].Biofactors, 2009, 35 (2) :200-208.

[7]Chen CC, Chen N, Lau LF.The angiogenic factor induce adhesivesignaling primary human skin fibroblasts[J].Biol Chem, 2001, 276:10443-10452.

[8]杨敏, 黄海长, 王海燕.结缔组织生长因子促纤维化作用及其表达调节的研究进展[J].中国病理生理杂志, 2005, 21 (1) :199-202, 208.

[9]Yokoi H, Mukoyama M, Sugawara A, et al.Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis[J].Physiol Renal Physiol, 2002, 282 (5) :F933-942.

[10]IHN H.Pathogenesis of fibrosis:role of TGF-beta and CTGF[J].Curr Opin Rheumatol, 2002, 14 (6) :681-685.

[11]Weston BS, Wahab NA, Mason RM.CTGF mediates TGF-beta-induced fibronectin matrix deposition by upregulating active alpha5betal integrin in human mesangial cells[J].Soc Nephrol, 2003, 14 (3) :601-610.

[12]金珍婧, 迟宝荣, 马丽娜, 等.CTGF-mRNA在实验性肝纤维化中的表达[J].吉林大学学报 (医学版) , 2005, 31 (1) :55-57.

[13]Blom IE, Goldschmeding R, Leask A.Gene regulation of connective tissue growth factor:new targets for antifibrotic therapy[J].Matrix Biol, 2002, 21:473-482.

[14]梁增文, 张国, 农兵.结缔组织生长因子在人及大鼠肝纤维化组织中表达增强[J].基础医学与临床, 2007, 27 (1) :49-52.

[15]Huang G, Brigstock DR.Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2) [J].Cell Mol Med, 2010, 19 (1) , 4-5.

[16]Gao RP, Brigstock DR.Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function[J].World J Gastroenterol, 2009, 15 (30) :3807-3013.

[17]Dessein A, Chevillard C, Arnaud V, et al.Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes[J].J Exp Med, 2009, 206 (11) :2321-2328.

[18]杨林, 王念跃, 张岱, 等.血清结缔组织生长因子在肝纤维化评估中的临床价值[J].中国生化药物杂志, 2009, 30 (6) :393-396.

[19]王念跃, 张岱, 杨成保.血清结缔组织生长因子对慢性肝病的诊断价值[J].临床检验杂志, 2009, 27 (1) :28-30.

[20]Wu GQ, Liu NF, Van XB, et al.The level of connective tissue growth factor in sera of patients with hepatitis B virus strongly correlates with stage of hepatic fibrosis[J].Viral Immunol, 2010, 23 (1) :71-78.

[21]Kovalenko E, Tacke F, Gressner OA, et al.Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis[J].Viral Hepat.2009, 16 (9) :612-620.

[22]Xie JJ, Xu LY, Wu JY, et al.Involvement of CYR61 and CTGF in the fascin-mediated proliferation and invasiveness of esophageal squamous cell carcinomas cells[J].Am J Pathol, 2010, 176 (2) :939-951.

[23]主余华, 任万华, 张春清.RNA干扰抑制肝星状细胞CTGF表达对细胞外基质分泌的影响[J].中国病理生理杂志, 2008, 24 (11) :2245-2250.

[24]Yu FJ, Dong PH, Fan XF, et al.Down-regulation of ang-iotensin II by shRNA reduces collagen synthesis in hepatic stellate cells[J].Mol Med, 2010, 25 (5) :801-806.

[25]Mazzocca A, Fransvea E, Dituri F, et al.Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma[J].Hepatology, 2010, 51 (2) :523-534.

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