自身免疫性肝炎的病理特点

王泰龄; 赵新颜

自身免疫性肝炎的病理特点

1. 中日友好医院病理科
2. 首都医科大学附属北京友谊医院肝病中心

详细信息

中图分类号: R575.1
计量
- 文章访问数: 2499
- HTML全文浏览量: 26
- PDF下载量: 1272
- 被引次数: 0
出版历程
- 收稿日期: 2010-11-12
- 出版日期: 2011-06-20

Pathological features of autoimmune hepatitis

摘要

摘要: 本文简要介绍了自身免疫性肝炎(AIH)发病机制的进展,阐述了AIH活动期和缓解期的病理形态特点及缓解的病理诊断标准。AIH的病理组织学特点为淋巴浆细胞性界面炎。急性加重或急性发病可呈现明显的小叶中心带坏死,这些病变中浆细胞成簇是诊断AIH的重要依据。肝穿病理形态有助于澄清其他自身抗体阳性的慢性肝病。并介绍了IgG4相关性自身免疫性肝炎和原位自身免疫性肝炎的病理特点。
- 肝炎,自身免疫性 /
- 病理学,临床
Abstract: We introduced the latest progression on the pathogenesis of AIH and thoroughly described pathological features of AIH in its active phase and diagnostic criterion in its quiescent phase.Liver pathology is the key exam to rule out other diseases which may confused with AIH.The characteristic feature is lymphoplasmacytic inferface hepatitis usually including clusters of plasma cells.IgG4 associated AIH and de novo AIH is also discussed in the review.
- hepatitis /
- autoimmune

HTML全文

参考文献(23)

[1]Manns MP, Czaja AJ, Gorham JD, et al.Diagnosis and management of autoimmune hepatitis[J].Hepatology, 2010, 51 (6) :2193-2213.

[2]Teufel A, Galle PR, Kanzler S.Update on autoimmune hepatitis[J].World J Gastroenterol, 2009, 15 (9) :1035-1041.

[3]Umemura T, Zen Y, Hamano H, et al.IgG4 associated autoimune hepatitis:a differential diagnosis for classical autoimmune hepatitis[J].Gut, 2007, 56 (10) :1471-1472.

[4]Czaja AJ.Current concepts in autoimmune hepatitis[J].Ann Hepatol, 2005, 4 (1) :6-24.

[5]Czaja AJ.Autoimmune liver disease[J].Curr Opin Gastroenterol, 2007, 23 (3) :255-262.

[6]Oo YH, Hubscher SG, Adams DH.Autoimmune hepatitis:new paradigms in the pathogenesis, diagnosis, and management[J].Hepatol Int, 2010, 4 (2) :475-493.J Clini Hepatol, June 2011, Vol.27, No.6

[7]Longhi MS, Ma Y, Meili-Vergani G, et al.Adaptive immunity in autoimmune hepatitis[J].Dig Dis, 2010, 28 (1) :63-69.

[8]Ishak KG.Pathologic features of chronic hepatitis.A review and update[J].Am J Clinical Pathol, 2000, 113 (1) :40-55.

[9]Iwai M, Jo M, Ishii M, et al.Comparison of clinical features and liver histology in acute and chronic autoimmune hepatitis[J].Hepatol Res, 2008, 38 (8) :784-789.

[10]Lefkowitch JH.Chronic hepatitis in Scheuer's Liver biopsy interpretation[M].8th.USA:Elesvier, 2010:133-161.

[11]Zen Y, Notsumat K, Tanaka N, et al.Hepatic centrilobular zonal necrosis with positive antinuclear antibody:a unique subtype or early disease of autoimmune hepatitis[J].Hum Pathol, 2007, 38 (11) :1669-1675.

[12]Misdraji J, Thiim M, Graeme-Cook FM, et al.Autoimmune hepatitis with Centrilobular necrosis[J].Am J Surg Pathol, 2004, 28 (4) :471-478.

[13]Odze RD, Goldblum JR.Surgical pathology of the GI tract, liver, biliary tract and pancreas 2nd[M].Philadelphia, PA:Saunders Elesvier, 2009:1035-1043.

[14]Burt AD, Portmann BC, Ferrell LD.McsWeen's Pathology of the liver 5th[M].Philadelphia, PA:Churchill livingstone Elsevir, 2007:493-515.

[15]Umemura T, Zen Y, Hamano H, et al.Immunoglobin G4-hepatopathy:association of immunglobin G4-bearing Plasma cells in liver with autoimmune pancreatitis[J].Hepatology, 2007, 46 (2) :463-471.

[16]Chung H, Watanabe T, Kudo M, et al.Identification and characterization of IgG4-associated autoimmune hepatitis[J].Liver Int, 2010, 30 (2) :222-231.

[17]Umemura T, Zen Y, Hamano H, et al.Clinical significance of immunoglobulin G4-associated autoimmune hepatitis[J].J Gastroenterol, 2011, 46 (Suppl 1) :48-55.

[18]Mieli-Vergani G, Vergani D.De novo autoimmune hepatitis[J].J Hepatol, 2004, 40 (1) :3-7.

[19]Kerkar N, HadzicN, Davies ET, et al.De-novo autoimmune hepatitis after liver transplantation[J].Lancet, 1998, 351 (9100) :409-413.

[20]Berardis, Lodato F, Gramenzi A, et al.High incidence of allograft dysfunction i liver transplanted patients treated with pegylated-interferon alpha-2b and ribavirin for hepatitis C recurrence:possible de novo autoimmune hepatitis[J].Gut, 2007, 56 (2) :237-242.

[21]Zhang Y, Wang B, Wang T.De novo autoimmune hepatitis with centrilobular necrosis following liver transplantion for primary biliary cirrhosis:a case report[J].Transplant Proc, 2010, 42 (9) :3854-3857.

[22]Fiel MI, Agarwal K, Stanca C, et al.Posttransplant plasma cell hepatitis (de novo autoimmune hepatitis) is a variant of rejection and may lead to a negative outcome in patients with hepatitis C virus[J].Liver Transpl, 2008, 14 (6) :861-871.

[23]Demetris AJ, Sebagh M.Plasma cell hepatitis in liver allografts:variant of rejection or autoimmune hepatitis[J].Liver Transpl, 2008, 14 (6) :750-755.

施引文献

资源附件(0)

访问统计