原发性胆汁性肝硬化的治疗进展

段维佳; 尤红

原发性胆汁性肝硬化的治疗进展

段维佳,
尤红

首都医科大学附属北京友谊医院肝病中心

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2011-02-09
- 出版日期: 2011-06-20

Therapy advances in primary biliary cirrhosis

摘要

摘要: 原发性胆汁性肝硬化(PBC)是一种慢性肝内胆汁淤积性疾病。熊去氧胆酸(UDCA)是惟一经随机对照临床试验证实的治疗PBC安全有效的药物。经UDCA治疗1年后有较好生化应答的患者,其长期预后较好。目前,对UDCA应答欠佳患者的治疗方法尚不确定。肝移植是治疗终末期PBC患者惟一有效的方法。
- 肝硬化 /
- 胆汁性
Abstract: Primary biliary cirrhosis (PBC) is a chronic intrahepatic cholestatic disease.Ursodeoxycholic acid (UDCA) is the only safe and effective drug for the treatment of PBC proven by randomized controlled clinical trials.Favorable long-term effects of UDCA are observed in patients with good biochemical response after one year treatment.There is currently no consensus on how to treat patients with a suboptimal biochemical response to UDCA.Liver transplantation is the only therapeutic option for end-stage patients.
- liver cirrhosis /
- biliary

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参考文献(23)

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