自身免疫性肝病重叠综合征的诊断与治疗

卞兆连; 尤征瑞; 马雄

自身免疫性肝病重叠综合征的诊断与治疗

上海交通大学医学院附属仁济医院上海市消化疾病研究所

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2011-01-25
- 出版日期: 2011-06-20

The clinical analysis on endoscope technique applicated for patients suffering from extrahepatic cholestatic jaundice

摘要

摘要: 近年来,自身免疫性肝病及其重叠综合征受到越来越多的关注。由于重叠综合征的发病率低,难以进行大规模的随机对照研究,导致该类疾病的诊断以及治疗方案没有统一标准,本文就该病的诊断及治疗做一综述。
- 肝疾病 /
- 自身免疫疾病 /
- 重叠综合征
Abstract: Recently, there are more and more studies on the overlap syndromes of autoimmune liver diseases.It is difficult to carry out large-scale randomized controlled studies because of the relatively low incidence.There is no consensus of the diagnosis and treatment of these diseases.In this review, we introduced the diagnosis and management of the overlap syndromes.
- liver diseases /
- autoimmune diseases /
- overlap syndromes

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参考文献(41)

[1]Beuers U.Hepatic overlap syndromes[J].J Hepatol, 2005, 42 (Suppl 1) :S93-99.

[2]Rust C, Beuers U.Overlap syndromes among autoimmune liver diseases[J].World J Gastroenterol, 2008, 14 (21) :3368-3373.

[3]Silveira MG, Lindor KD.Overlap syndromes with autoimmune hepatitis in chronic cholestatic liver diseases[J].Expert Rev Gastroenterol Hepatol, 2007, 1 (2) :329-340.

[4]Burak KW, Urbanski SJ, Swain MG.A case of coexisting primary biliary cirrhosis and primary sclerosing cholangitis:a new overlap of autoimmune liver diseases[J].Dig Dis Sci, 2001, 46 (9) :2043-2047.

[5]Durazzo M, Premoli A, Fagoonee S, et al.Overlap syndromes of autoimmune hepatitis:what is known so far[J].Dig Dis Sci, 2003, 48 (3) :423-430.

[6]Toyoda M, Yokomori H, Kaneko F, et al.Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome concomitant with systemic sclerosis, immune thrombocytopenic purpura[J].Intern Med, 2009, 48 (23) :2019-2023.

[7]Yokokawa J, Saito H, Kanno Y, et al.Overlap of primary biliary cirrhosis and autoimmune hepatitis:Characteristics, therapy, and long term outcomes[J].J Gastroenterol Hepatol, 25 (2) :376-382.

[8]Muratori L, Cassani F, Pappas G, et al.The hepatitic/cholestatic"overlap"syndrome:an Italian experience[J].Autoimmunity, 2002, 35 (8) :565-568.

[9]Floreani A, Rizzotto ER, Ferrara F, et al.Clinical course and outcome of autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome[J].Am J Gastroenterol, 2005, 100 (7) :1516-1522.

[10]Olsson R, Glaumann H, Almer S, et al.High prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis[J].Eur J Intern Med, 2009, 20 (2) :190-196.

[11]Muratori P, Granito A, Pappas G, et al.The serological profile of the autoimmune hepatitis/primary biliary cirrhosis overlap syndrome[J].Am J Gastroenterol, 2009, 104 (6) :1420-1425.

[12]European Association for the Study of the Liver.EASL clinical practice guidelines:management of cholestatic liver diseases[J].J Hepatol, 2009, 51 (2) :237-267.

[13]Czaja AJ.Frequency and nature of the variant syndromes of autoimmune liver disease[J].Hepatology, 1998, 28 (2) :360-365.

[14]O'Brien C, Joshi S, Feld JJ, et al.Long-term follow-up of antimitochondrial antibody-positive autoimmune hepatitis[J].Hepatology, 2008, 48 (2) :550-556.

[15]Papamichalis PA, Zachou K, Koukoulis GK, et al.The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders[J].J Autoimmune Dis, 2007, 4:3.

[16]Neuhauser M, Bjornsson E, Treeprasertsuk S, et al.Autoimmune hepatitis-PBC overlap syndrome:a simplified scoring system J Clini Hepatol, June 2011, Vol.27, No.6may assist in the diagnosis[J].Am J Gastroenterol, 105 (2) :345-353.

[17]Kuiper EM, Zondervan PE, van Buuren HR.Paris criteria are effective in diagnosis of primary biliary cirrhosis and autoimmune hepatitis overlap syndrome[J].Clin Gastroenterol Hepatol, 8 (6) :530-534.

[18]Joshi S, Cauch-Dudek K, Wanless IR, et al.Primary biliary cirrhosis with additional features of autoimmune hepatitis:response to therapy with ursodeoxycholic acid[J].Hepatology, 2002, 35 (2) :409-413.

[19]Renou C, Bourliere M, Martini F, et al.Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome:complete biochemical and histological response to therapy with ursodesoxycholic acid[J].J Gastroenterol Hepatol, 2006, 21 (4) :781-782.

[20]Al-Chalabi T, Portmann BC, Bernal W, et al.Autoimmune hepatitis overlap syndromes:an evaluation of treatment response, long-term outcome and survival[J].Aliment Pharmacol Ther, 2008, 28 (2) :209-220.

[21]Alric L, Thebault S, Selves J, et al.Characterization of overlap syndrome between primary biliary cirrhosis and autoimmune hepatitis according to antimitochondrial antibodies status[J].Gastroenterol Clin Biol, 2007, 31 (1) :11-16.

[22]Chazouilleres O, Wendum D, Serfaty L, et al.Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome[J].J Hepatol, 2006, 44 (2) :400-406.

[23]Gunsar F, Akarca US, Ersoz G, et al.Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosis-autoimmune hepatitis overlap syndrome[J].Hepatogastroenterology, 2002, 49 (47) :1195-1200.

[24]Heurgue A, Vitry F, Diebold MD, et al.Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis:a retrospective study of 115 cases of autoimmune liver disease[J].Gastroenterol Clin Biol, 2007, 31 (1) :17-25.

[25]Csepregi A, Rocken C, Treiber G, et al.Budesonide induces complete remission in autoimmune hepatitis[J].World J Gastroenterol, 2006, 12 (9) :1362-1366.

[26]Wiegand J, Schuler A, Kanzler S, et al.Budesonide in previously untreated autoimmune hepatitis[J].Liver Int, 2005, 25 (5) :927-934.

[27]Duclos-Vallée JC, Hadengue A, Ganne-Carrie N, et al.Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome.Corticoresistance and effective treatment by cyclosporine A[J].Dig Dis Sci, 1995, 40 (5) :1069-1073.

[28]Kaya M, Angulo P, Lindor KD.Overlap of autoimmune hepatitis and primary sclerosing cholangitis:an evaluation of a modified scoring system[J].J Hepatol, 2000, 33 (4) :537-542.

[29]Johnson PJ, McFarlane IG.Meeting report:International Autoimmune Hepatitis Group[J].Hepatology, 1993, 18 (4) :998-1005.

[30]Alvarez F, Berg PA, Bianchi FB, et al.International Autoimmune Hepatitis Group Report:review of criteria for diagnosis of autoimmune hepatitis[J].J Hepatol, 1999, 31 (5) :929-938.

[31]Chandok N, Silveira MG, Lindor KD.Comparing the simplified and international autoimmune hepatitis group criteria in primary sclerosing cholangitis[J].Gastroenterol Hepatol (N Y) , 2010, 6 (2) :108-112.

[32]Mitchell SA, Bansi DS, Hunt N, et al.A preliminary trial of high-dose ursodeoxycholic acid in primary sclerosing cholangitis[J].Gastroenterology, 2001, 121 (4) :900-907.

[33]Silveira MG, Lindor KD.High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis[J].J Hepatol, 2008, 48 (5) :692-694.

[34]Cullen SN, Rust C, Fleming K, et al.High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective[J].J Hepatol, 2008, 48 (5) :792-800.

[35]Gregorio GV, Portmann B, Karani J, et al.Autoimmune hepatitis/sclerosing cholangitis overlap syndrome in childhood:a 16-year prospective study[J].Hepatology, 2001, 33 (3) :544-553.

[36]Rubel LR, Seeff LB, Patel V.Primary biliary cirrhosis-primary sclerosing cholangitis overlap syndrome[J].Arch Pathol Lab Med, 1984, 108 (5) :360-361.

[37]Jeevagan A.Overlap of primary biliary cirrhosis and primary sclerosing cholangitis-a rare coincidence or a new syndrome[J].Int J Gen Med, 2010, 3:143-146.

[38]Brunner G, Klinge O.A chronic destructive non-suppurative cholangitis-like disease picture with antinuclear antibodies (immunocholangitis) [J].Dtsch Med Wochenschr, 1987, 112 (38) :1454-1458.

[39]Sakauchi F, Mori M, Zeniya M, et al.Antimitochondrial antibody negative primary biliary cirrhosis in Japan:utilization of clinical data when patients applied to receive public financial aid[J].J Epidemiol, 2006, 16 (1) :30-34.

[40]Mendes F, Lindor KD.Antimitochondrial antibody-negative primary biliary cirrhosis[J].Gastroenterol Clin North Am, 2008, 37:479-484, viii.

[41]Li CP, Tong MJ, Hwang SJ, et al.Autoimmune cholangitis with features of autoimmune hepatitis:successful treatment with immunosuppressive agents and ursodeoxycholic acid[J].J Gastroenterol Hepatol, 2000, 15 (1) :95-98.

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