慢性乙型肝炎合并肝脂肪变的临床病理学特点及相关因素分析

邹志强; 强春倩; 李艳芳; 刘友德; 郎振为

慢性乙型肝炎合并肝脂肪变的临床病理学特点及相关因素分析

烟台市传染病医院

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中图分类号: R512.62
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- 出版日期: 2011-06-20

The clinical features and related factors of chronic hepatitis B with hepatic steatosis

摘要

摘要: 目的探讨慢性乙型肝炎(CHB)合并脂肪肝的临床病理学特征及相关因素。方法病例选自2008年7月~2009年12月期间有肝活组织检查的CHB患者306例,根据肝组织中脂肪变肝细胞<5%小叶内肝细胞者为CHB组,脂肪变肝细胞>5%者,为CHB合并脂肪肝组。对两组的临床与病理特征进行比较。结果 306例CHB患者中,合并肝脂肪变141例(46.1%),不合并肝脂肪变165例(53.9%)。各种临床生化及病理指标中,高体重指数(P<0.0001)和性别(P=0.008)是CHB患者合并肝细胞脂肪变的危险因素,与患者年龄、血糖、胆固醇和肝组织学炎症分级和分期无关(P>0.05)。结论 CHB合并肝脂肪变的发生主要与高体重指数及男性相关。
- 肝炎,乙型,慢性 /
- 脂肪肝 /
- 人体质量指数
Abstract: Objective To study the clinic-pathological characteristics and related factors in the patients of chronic hepatitis B with hepatic steatosis.Methods A total of 306 cases of chronic hepatitis B were chosen for this study, and divided into two groups according to the percentage of hepatic steatosis less than 5% or more than 5%.The two groups were compared regarding the presence of risk factors for steatosis and clinical laboratory, virological and histological characteristics.Results Among 306 chronic hepatitis B patients, there were 141 cases with steatosis (46.1%) and 165 cases without steatosis (53.9%) , respectively.High body mass index (BMI) and sex were independent factors and significantly higher in steatosis group than that in the group without steatosis (P<0.0001 and P=0.008, respectively) .No significant difference were found in the other parameters between two groups, including age, blood sugar, cholesterol, viral load, histological activity (HAI) and stage (P>0.05) .Conclusion The risk factors mainly related to steatosis were high body mass index and sex in chronic hepatitis B with steatosis.
- hepatitis B /
- chronic /
- fatty liver

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参考文献(16)

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