铁超载与肝细胞癌关系的研究进展

赵睿; 张岭漪

铁超载与肝细胞癌关系的研究进展

赵睿,
张岭漪

兰州大学第二医院肝病科甘肃省消化系肿瘤重点实验室

基金项目:

甘肃省自然科学基金(1010RJZA087)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2011-06-20

Recent progress in relationship between iron overload and hepatocellular carcinoma

Research funding:

摘要

摘要: 肝细胞癌(HCC)的发生与多种因素有关。早期的流行病学研究显示非洲人群饮食中铁过量与HCC发生相关,继而研究发现许多与铁沉积相关的疾病如遗传性血色素沉积症(HH)、丙型病毒性肝炎、非酒精性脂肪性肝病(NAFLD)等在发展过程中均有发生HCC的可能性,提示铁超载可能在其中发挥着直接或间接的作用。现认为铁超载的发生与基因突变、铁代谢相关基因蛋白的异常表达、氧化应激反应、免疫紊乱、促进癌细胞生长等因素有关。本文就铁超载与HCC的相关研究现状作一综述。
- 肝肿瘤 /
- 铁
Abstract: Hepatocellular carcinoma (HCC) is associated with many specific etiologies.Some epidemiological investigations has shown that dietary iron overload is associated with HCC in Africans.And subsequent studies found that many iron-loading diseases, such as hereditary hemochromatosis, chronic hepatitis C, nonalcoholic fatty liver disease etc, appeared to increase the risk of HCC with the development of these diseases.The carcinogenic potential of these iron-loading diseases is probably mainly associated with genetic mutation, abnormal expression of iron metabolism related proteins, oxidative stress reaction, immune disorder and so on.We summarized the recent findings concerning the correlation between iron-loading diseases and HCC.
- liver neoplasms /
- iron

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参考文献(27)

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