钆塞酸二钠增强MRI扫描评估肝肿瘤术后残留肝组织储备功能的研究现状

叶彦宏; 陆力坚

doi:10.12449/JCH240226

钆塞酸二钠增强MRI扫描评估肝肿瘤术后残留肝组织储备功能的研究现状

DOI: 10.12449/JCH240226

叶彦宏,
陆力坚^, ,

广西医科大学附属武鸣医院放射科，南宁 530021

基金项目:

广西医疗卫生适宜技术开发与推广应用项目 (S2020045)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：叶彦宏负责起草论文；陆力坚负责论文修改，拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
陆力坚， lulijiannet@163.com （ORCID： 0000-0002-5605-9031）

计量
- 文章访问数: 339
- HTML全文浏览量: 131
- PDF下载量: 46
- 被引次数: 0
出版历程
- 收稿日期: 2023-05-20
- 录用日期: 2023-07-04
- 出版日期: 2024-02-19

Current research status of Gd-EOB-DTPA-enhanced MRI in evaluating liver reserve function in residual liver tissue after liver tumor surgery

Yanhong YE,
Lijian LU^{,
,}

Department of Radiology，Wuming Hospital of Guangxi Medical University，Nanning 530021，China

Research funding:

Guangxi Medical and Health Appropriate Technology Development and Application Project (S2020045)

More Information

Corresponding author: LU Lijian， lulijiannet@163.com （ORCID： 0000-0002-5605-9031）

摘要

摘要: 钆塞酸二钠（Gd-EOB-DTPA）增强MRI扫描作为一种无创、简便、可重复的检查手段，在肝储备功能评价中具有重要应用价值。目前在临床上，主要采用Gd-EOB-DTPA增强MRI测量肝实质信号强度参数、磁共振弛豫时间参数、胆道强化参数以及肝体积参数等来评价患者的肝储备功能。近年来，利用Gd-EOB-DTPA增强MRI评估肝肿瘤术后残留肝组织储备功能是临床研究的热点之一，国内外的相关研究也取得了一定的进展，本文对近年来的相关研究进展作一综述。
- 肝肿瘤 /
- 磁共振成像 /
- 钆塞酸二钠
Abstract: As a non-invasive， simple， and reproducible examination， Gd-EOB-DTPA-enhanced magnetic resonance imaging （MRI） has an important application value in evaluating liver reserve function. Currently in clinical practice， Gd-EOB-DTPA-enhanced MRI is mainly used to measure liver parenchymal signal intensity parameters， magnetic resonance relaxation time parameters， biliary tract enhancement parameters， and liver volume parameters to evaluate the liver reserve function of patients. In recent years， the use of Gd-EOB-DTPA-enhanced MRI in predicting liver reserve function in residual liver tissue after liver tumor surgery has become one of the hotspots in clinical research， and certain progress has been made in related studies in China and globally. This article reviews the research advances in recent years.
- Liver Neoplasms /
- Magnetic Resonance Imaging /
- Gd-EOB-DTPA

HTML全文

参考文献(55)

[1]	LIU ZC, LI ZX, ZHANG Y, et al. Interpretation on the report of global cancer statistics 2020[J/CD]. J Multidiscip Cancer Manag Electron Version, 2021, 7( 2): 1- 14. DOI: 10.12151/JMCM.2021.02-01. 刘宗超, 李哲轩, 张阳, 等. 2020全球癌症统计报告解读[J/CD]. 肿瘤综合治疗电子杂志, 2021, 7( 2): 1- 14. DOI: 10.12151/JMCM.2021.02-01.
[2]	LI Z, ZHU JY. Interpretation of Standard for diagnosis and treatment of primary liver cancer(2022 edition)[J]. J Clin Hepatol, 2022, 38( 5): 1027- 1029. DOI: 10.3969/j.issn.1001-5256.2022.05.010. 李照, 朱继业.《原发性肝癌诊疗指南(2022年版)》解读[J]. 临床肝胆病杂志, 2022, 38( 5): 1027- 1029. DOI: 10.3969/j.issn.1001-5256.2022.05.010.
[3]	GRUTTADAURIA S, VASTA F, MINERVINI MI, et al. Significance of the effective remnant liver volume in major hepatectomies[J]. Am Surg, 2005, 71( 3): 235- 240.
[4]	PEI JP, DING YM. Methods for evaluating liver reserve function before hepatectomy[J]. J Clin Hepatol, 2023, 39( 5): 1219- 1226. DOI: 10.3969/j.issn.1001-5256.2023.05.034. 裴俊鹏, 丁佑铭. 肝切除术前肝储备功能的评估方法[J]. 临床肝胆病杂志, 2023, 39( 5): 1219- 1226. DOI: 10.3969/j.issn.1001-5256.2023.05.034.
[5]	PASTOR CM, VILGRAIN V. Steatosis alters the activity of hepatocyte membrane transporters in obese rats[J]. Cells, 2021, 10( 10): 2733. DOI: 10.3390/cells10102733.
[6]	ZHOU XJ, LONG LL, MO ZQ, et al. OATP1B3 expression in hepatocellular carcinoma correlates with intralesional Gd-EOB-DTPA uptake and signal intensity on Gd-EOB-DTPA-enhanced MRI[J]. Cancer Manag Res, 2021, 13: 1169- 1177. DOI: 10.2147/CMAR.S292197.
[7]	KATSUBE T, OKADA M, KUMANO S, et al. Estimation of liver function using T2* mapping on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging[J]. Eur J Radiol, 2012, 81( 7): 1460- 1464. DOI: 10.1016/j.ejrad.2011.03.073.
[8]	RASSAM F, ZHANG T, CIESLAK KP, et al. Comparison between dynamic gadoxetate-enhanced MRI and(99m)Tc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function[J]. Eur Radiol, 2019, 29( 9): 5063- 5072. DOI: 10.1007/s00330-019-06029-7.
[9]	KIM DK, CHOI JI, CHOI MH, et al. Prediction of posthepatectomy liver failure: MRI with hepatocyte-specific contrast agent versus indocyanine green clearance test[J]. AJR Am J Roentgenol, 2018, 211( 3): 580- 587. DOI: 10.2214/AJR.17.19206.
[10]	BEER L, MANDORFER M, BASTATI N, et al. Inter- and intra-reader agreement for gadoxetic acid-enhanced MRI parameter readings in patients with chronic liver diseases[J]. Eur Radiol, 2019, 29( 12): 6600- 6610. DOI: 10.1007/s00330-019-06182-z.
[11]	THEILIG D, STEFFEN I, MALINOWSKI M, et al. Predicting liver failure after extended right hepatectomy following right portal vein embolization with gadoxetic acid-enhanced MRI[J]. Eur Radiol, 2019, 29( 11): 5861- 5872. DOI: 10.1007/s00330-019-06101-2.
[12]	CAPARROZ C, FORNER A, RIMOLA J, et al. Portal hypertension may influence the registration of hypointensity of small hepatocellular carcinoma in the hepatobiliary phase in gadoxetic acid MR[J]. Radiol Oncol, 2022, 56( 3): 292- 302. DOI: 10.2478/raon-2022-0024.
[13]	KUDO M, GOTOHDA N, SUGIMOTO M, et al. Evaluation of liver function using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging based on a three-dimensional volumetric analysis system[J]. Hepatol Int, 2018, 12( 4): 368- 376. DOI: 10.1007/s12072-018-9874-x.
[14]	ÖCAL O, PEYNIRCIOGLU B, LOEWE C, et al. Correlation of liver enhancement in gadoxetic acid-enhanced MRI with liver functions: A multicenter-multivendor analysis of hepatocellular carcinoma patients from SORAMIC trial[J]. Eur Radiol, 2022, 32( 2): 1320- 1329. DOI: 10.1007/s00330-021-08218-9.
[15]	KUDO M, GOTOHDA N, SUGIMOTO M, et al. The assessment of regional liver function before major hepatectomy using magnetic resonance imaging[J]. Am Surg, 2022, 88( 9): 2353- 2360. DOI: 10.1177/00031348211011095.
[16]	ZHANG JY, LU J, ZHANG XQ, et al. Evaluation of liver reserve function with Gd-EOB-DTPA enhanced MRI in patients with hepatitis B cirrhosis[J]. J Pract Radiol, 2017, 33( 12): 1870- 1873. DOI: 10.3969/j.issn.1002-1671.2017.12.015. 张继云, 陆健, 张学琴, 等. Gd-EOB-DTPA增强MRI评估乙肝肝硬化患者肝脏储备功能[J]. 实用放射学杂志, 2017, 33( 12): 1870- 1873. DOI: 10.3969/j.issn.1002-1671.2017.12.015.
[17]	SHAO J. Research of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid enhanced magnetic resonance imaging in evaluating liver function[D]. Taiyuan: Shanxi Medical University, 2021. 邵佳. 应用钆塞酸二钠增强磁共振成像评估肝功能的研究[D]. 太原: 山西医科大学, 2021.
[18]	WANG Q, BRISMAR TB, GILG S, et al. Multimodal perioperative assessment of liver function and volume in patients undergoing hepatectomy for colorectal liver metastasis: A comparison of the indocyanine green retention test,(99m)Tc mebrofenin hepatobiliary scintigraphy and gadoxetic acid enhanced MRI[J]. Br J Radiol, 2022, 95( 1139): 20220370. DOI: 10.1259/bjr.20220370.
[19]	ZHANG WG, WANG X, MIAO YH, et al. Liver function correlates with liver-to-portal vein contrast ratio during the hepatobiliary phase with Gd-EOB-DTPA-enhanced MR at 3 Tesla[J]. Abdom Radiol, 2018, 43( 9): 2262- 2269. DOI: 10.1007/s00261-018-1462-y.
[20]	YANG M, ZHANG Y, ZHAO WL, et al. Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-D TPA-enhanced MRI[J]. BMC Med Imaging, 2020, 20( 1): 119. DOI: 10.1186/s12880-020-00519-7.
[21]	TAKATSU Y, NAKAMURA M, SHIOZAKI T, et al. Assessment of the cut-off value of quantitative liver-portal vein contrast ratio in the hepatobiliary phase of liver MRI[J]. Clin Radiol, 2021, 76( 7): 551. DOI: 10.1016/j.crad.2021.03.015.
[22]	HAIMERL M, VERLOH N, ZEMAN F, et al. Gd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry[J]. Sci Rep, 2017, 7: 43347. DOI: 10.1038/srep43347.
[23]	TSUJITA Y, SOFUE K, KOMATSU S, et al. Prediction of post-hepatectomy liver failure using gadoxetic acid-enhanced magnetic resonance imaging for hepatocellular carcinoma with portal vein invasion[J]. Eur J Radiol, 2020, 130: 109189. DOI: 10.1016/j.ejrad.2020.109189.
[24]	NOTAKE T, SHIMIZU A, KUBOTA K, et al. Hepatocellular uptake index obtained with gadoxetate disodium-enhanced magnetic resonance imaging in the assessment future liver remnant function after major hepatectomy for biliary malignancy[J]. BJS Open, 2021, 5( 4): zraa048. DOI: 10.1093/bjsopen/zraa048.
[25]	DONADON M, LANZA E, BRANCIFORTE B, et al. Hepatic uptake index in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine penta acetic acid-enhanced magnetic resonance imaging estimates functional liver reserve and predicts post-hepatectomy liver failure[J]. Surgery, 2020, 168( 3): 419- 425. DOI: 10.1016/j.surg.2020.04.041.
[26]	ORIMO T, KAMIYAMA T, KAMACHI H, et al. Predictive value of gadoxetic acid enhanced magnetic resonance imaging for posthepatectomy liver failure after a major hepatectomy[J]. J Hepatobiliary Pancreat Sci, 2020, 27( 8): 531- 540. DOI: 10.1002/jhbp.769.
[27]	CHUANG YH, OU HY, LAZO MZ, et al. Predicting post-hepatectomy liver failure by combined volumetric, functional MR image and laboratory analysis[J]. Liver Int, 2018, 38( 5): 868- 874. DOI: 10.1111/liv.13608.
[28]	SANDRASEGARAN K, CUI EM, ELKADY R, et al. Can functional parameters from hepatobiliary phase of gadoxetate MRI predict clinical outcomes in patients with cirrhosis?[J]. Eur Radiol, 2018, 28( 10): 4215- 4224. DOI: 10.1007/s00330-018-5366-6.
[29]	REN MJ, LI L, ZHAO J, et al. Preliminary study of the value of Gd-EOB-DTPA enhanced MRI in evaluation of reserved liver function patients with hepatitis B[J/CD]. Electron J Emerg Infect Dis, 2022, 7( 2): 63- 66. DOI: 10.19871/j.cnki.xfcrbzz.2022.02.013. 任美吉, 李莉, 赵晶, 等. 钆塞酸二钠增强MRI评估乙型病毒性肝炎患者肝脏储备功能的研究[J/CD]. 新发传染病电子杂志, 2022, 7( 2): 63- 66. DOI: 10.19871/j.cnki.xfcrbzz.2022.02.013.
[30]	LI J, CAO JP, ZHAO J, et al. The feasibility study of Gd-BOPTA-enhanced MRI in evaluating liver function to predict post-hepatectomy liver failure[J]. J Clin Radiol, 2019, 38( 2): 257- 260. DOI: 10.13437/j.cnki.jcr.2019.02.017. 李洁, 曹吉平, 赵静, 等. Gd-BOPTA增强MRI肝功能评估预测术后肝衰的可行性研究[J]. 临床放射学杂志, 2019, 38( 2): 257- 260. DOI: 10.13437/j.cnki.jcr.2019.02.017.
[31]	YOON JH, LEE JM, KANG HJ, et al. Quantitative assessment of liver function by using gadoxetic acid-enhanced MRI: Hepatocyte uptake ratio[J]. Radiology, 2019, 290( 1): 125- 133. DOI: 10.1148/radiol.2018180753.
[32]	PAN S, WANG XQ, GUO QY. Quantitative assessment of hepatic fibrosis in chronic hepatitis B and C: T1 mapping on Gd-EOB-DTPA-enhanced liver magnetic resonance imaging[J]. World J Gastroenterol, 2018, 24( 18): 2024- 2035. DOI: 10.3748/wjg.v24.i18.2024.
[33]	LIU MT, ZHANG XQ, LU J, et al. Evaluation of liver function using the hepatocyte enhancement fraction based on gadoxetic acid-enhanced MRI in patients with chronic hepatitis B[J]. Abdom Radiol, 2020, 45( 10): 3129- 3135. DOI: 10.1007/s00261-020-02478-7.
[34]	NODA Y, GOSHIMA S, OKUAKI T, et al. Hepatocyte fraction: Correlation with noninvasive liver functional biomarkers[J]. Abdom Radiol, 2020, 45( 1): 83- 89. DOI: 10.1007/s00261-019-02238-2.
[35]	BI XJ, ZHANG XQ, ZHANG T, et al. Quantitative assessment of liver function with hepatocyte fraction: Comparison with T1 relaxation-based indices[J]. Eur J Radiol, 2021, 141: 109779. DOI: 10.1016/j.ejrad.2021.109779.
[36]	LUETKENS JA, KLEIN S, TRÄBER F, et al. Quantification of liver fibrosis at T1 and T2 mapping with extracellular volume fraction MRI: Preclinical results[J]. Radiology, 2018, 288( 3): 748- 754. DOI: 10.1148/radiol.2018180051.
[37]	FAHLENKAMP UL, ZIEGELER K, ADAMS LC, et al. Intracellular accumulation capacity of gadoxetate: Initial results for a novel biomarker of liver function[J]. Sci Rep, 2020, 10( 1): 18104. DOI: 10.1038/s41598-020-75145-y.
[38]	ZHOU ZP, LONG LL, HUANG LJ, et al. Gd-EOB-DTPA-enhanced MRI T1 mapping for assessment of liver function in rabbit fibrosis model: Comparison of hepatobiliary phase images obtained at 10 and 20 Min[J]. Radiol Med, 2017, 122( 4): 239- 247. DOI: 10.1007/s11547-016-0719-1.
[39]	SHAIKH S. Editorial for“T1 mapping on Gd-EOB-DTPA-enhanced MRI for the prediction of oxaliplatin-induced liver injury in a mouse model”[J]. J Magn Reson Imaging, 2021, 53( 3): 903- 904. DOI: 10.1002/jmri.27465.
[40]	YANG L, DING Y, RAO S, et al. T1 mapping on Gd-EOB-DTPA-enhanced mri for the prediction of oxaliplatin-induced liver injury in a mouse model[J]. J Magn Reson Imaging, 2021, 53( 3): 896- 902. DOI: 10.1002/jmri.27377.
[41]	YOON JH, LEE JM, PAEK M, et al. Quantitative assessment of hepatic function: Modified look-locker inversion recovery(MOLLI) sequence for T1 mapping on Gd-EOB-DTPA-enhanced liver MR imaging[J]. Eur Radiol, 2016, 26( 6): 1775- 1782. DOI: 10.1007/s00330-015-3994-7.
[42]	KIM JE, KIM HO, BAE K, et al. T1 mapping for liver function evaluation in gadoxetic acid-enhanced MR imaging: comparison of look-locker inversion recovery and B1 inhomogeneity-corrected variable flip angle method[J]. Eur Radiol, 2019, 29( 7): 3584- 3594. DOI: 10.1007/s00330-018-5947-4.
[43]	YOO H, LEE JM, YOON JH, et al. T2* mapping from multi-echo Dixon sequence on gadoxetic acid-enhanced magnetic resonance imaging for the hepatic fat quantification: Can it be used for hepatic function assessment?[J]. Korean J Radiol, 2017, 18( 4): 682- 690. DOI: 10.3348/kjr.2017.18.4.682.
[44]	YANG W, KIM JE, CHOI HC, et al. T2 mapping in gadoxetic acid-enhanced MRI: Utility for predicting decompensation and death in cirrhosis[J]. Eur Radiol, 2021, 31( 11): 8376- 8387. DOI: 10.1007/s00330-021-07805-0.
[45]	LIU D, HUANG JY, HU CH. Effect of different liver function on contrast-enhanced MR cholangiography with Gd-EOB-DTPA[J]. J Med Imag, 2019, 29( 1): 70- 73, 94. 刘冬, 黄瑾瑜, 胡春洪. Gd-EOB-DTPA增强MRI胆道成像与不同级别肝硬化关系的研究[J]. 医学影像学杂志, 2019, 29( 1): 70- 73, 94.
[46]	LI LJ, JIA QL, LIU ZF, et al. Study on the relationship between Gd-EOB-DTPA enhanced MRI cholangiography and different grades of liver cirrhosis[J]. J Imag Res Med Appl, 2020, 4( 8): 70- 71. 李亮杰, 贾啟龙, 刘志飞, 等. Gd-EOB-DTPA增强MRI胆道成像与不同级别肝硬化关系的研究[J]. 影像研究与医学应用, 2020, 4( 8): 70- 71.
[47]	HAN D, LIU JY, JIN EH, et al. Liver assessment using Gd-EOB-DTPA-enhanced magnetic resonance imaging in primary biliary cholangitis patients[J]. Jpn J Radiol, 2019, 37( 5): 412- 419. DOI: 10.1007/s11604-019-00822-6.
[48]	YAMADA S, SHIMADA M, MORINE Y, et al. A new formula to calculate the resection limit in hepatectomy based on Gd-EOB-DTPA-enhanced magnetic resonance imaging[J]. PLoS One, 2019, 14( 1): e0210579. DOI: 10.1371/journal.pone.0210579.
[49]	ARAKI K, HARIMOTO N, KUBO N, et al. Functional remnant liver volumetry using Gd-EOB-DTPA-enhanced magnetic resonance imaging(MRI) predicts post-hepatectomy liver failure in resection of more than one segment[J]. HPB, 2020, 22( 2): 318- 327. DOI: 10.1016/j.hpb.2019.08.002.
[50]	WANG YJ, ZHANG L, NING J, et al. Preoperative remnant liver function evaluation using a routine clinical dynamic Gd-EOB-DTPA-enhanced MRI protocol in patients with hepatocellular carcinoma[J]. Ann Surg Oncol, 2021, 28( 7): 3672- 3682. DOI: 10.1245/s10434-020-09361-1.
[51]	CAI JL, WANG ZH, CHEN H, et al. The association between functional liver volume and liver function evaluated by quantitative analysis of gadoxetic acid-enhanced magnetic resonance imaging[J]. J Wenzhou Med Univ, 2020, 50( 8): 637- 641. DOI: 10.3969/j.issn.2095-9400.2020.08.007. 蔡佳乐, 王兆洪, 陈辉, 等. Gd-EOB-DTPA增强MRI评估功能性肝体积与肝功能Child-Pugh分级的相关性[J]. 温州医科大学学报, 2020, 50( 8): 637- 641. DOI: 10.3969/j.issn.2095-9400.2020.08.007.
[52]	DUAN T, JIANG HY, XIA CC, et al. Assessing liver function in liver tumors patients: The performance of T1 mapping and residual liver volume on Gd-EOBDTPA-enhanced MRI[J]. Front Med, 2020, 7: 215. DOI: 10.3389/fmed.2020.00215.
[53]	BASTATI N, WIBMER A, TAMANDL D, et al. Assessment of orthotopic liver transplant graft survival on gadoxetic acid-enhanced magnetic resonance imaging using qualitative and quantitative parameters[J]. Invest Radiol, 2016, 51( 11): 728- 734. DOI: 10.1097/RLI.0000000000000286.
[54]	BASTATI N, BEER L, BA-SSALAMAH A, et al. Gadoxetic acid-enhanced MRI-derived functional liver imaging score(FLIS) and spleen diameter predict outcomes in ACLD[J]. J Hepatol, 2022, 77( 4): 1005- 1013. DOI: 10.1016/j.jhep.2022.04.032.
[55]	DU YN, LYU ZB, GUAN CS, et al. A comparative study of FLIS and three features derived from gadoxetic acid-enhanced MRI with child-turcotte-pugh classification[J]. J Clin Radiol, 2021, 40( 11): 2134- 2138. DOI: 10.13437/j.cnki.jcr.2021.11.019. 杜艳妮, 吕志彬, 关春爽, 等. 钆塞酸二钠增强MRI功能性肝脏影像评分影像征象与Child-Turcotte-Pugh分级评估肝功能的对照研究[J]. 临床放射学杂志, 2021, 40( 11): 2134- 2138. DOI: 10.13437/j.cnki.jcr.2021.11.019.