重视病理活检，关注自身免疫性肝炎/胰腺炎病理学进展

滕晓东

doi:10.12449/JCH240601

重视病理活检，关注自身免疫性肝炎/胰腺炎病理学进展

DOI: 10.12449/JCH240601

滕晓东^, ,

浙江大学医学院附属第一医院病理科，杭州 310003

利益冲突声明：本文不存在任何利益冲突。

详细信息

通信作者:
滕晓东， teng1102069@zju.edu.cn （ORCID： 0000-0002-8700-4770）

计量
- 文章访问数: 261
- HTML全文浏览量: 132
- PDF下载量: 58
- 被引次数: 0
出版历程
- 收稿日期: 2024-05-11
- 录用日期: 2024-05-20
- 出版日期: 2024-06-25

Value of biopsy in evaluating the pathological progression of autoimmune hepatitis/pancreatitis

Xiaodong TENG^{,
,}

Department of Pathology，The First Affiliated Hospital，Zhejiang University School of Medicine，Hangzhou 310003，China

More Information

Corresponding author: TENG Xiaodong， teng1102069@zju.edu.cn （ORCID： 0000-0002-8700-4770）

摘要

摘要: 肝活检可以直接观察病变的形态学改变，有助于对相关病变进行准确评估，对慢性肝病诊断具有重要价值。自身免疫性肝炎形态复杂，掌握分级分期标准以及重叠综合征判断的同时应关注免疫介导性肝炎和接种新冠疫苗后自身免疫性肝炎形态特征。自身免疫性胰腺炎1型和2型形态明显不同，同时3型自身免疫性胰腺炎需要更多研究。
- 活组织检查 /
- 肝炎，自身免疫性 /
- 自身免疫性胰腺炎 /
- 病理学 /
- 诊断
Abstract: Liver biopsy is a crucial diagnostic tool for chronic liver diseases， allowing for direct observation of lesion morphology and aiding in precise evaluation. It is especially valuable in cases of autoimmune hepatitis， which exhibits complex morphological characteristics. This includes assessing grading and staging criteria， recognizing overlap syndrome， and considering the morphological features of immune-mediated hepatitis and post-COVID-19 vaccination autoimmune hepatitis. Furthermore， significant morphological differences exist between type 1 and type 2 autoimmune pancreatitis， necessitating further research into type 3 autoimmune pancreatitis.
- Biopsy /
- Hepatitis， Autoimmune /
- Autoimmune Pancreatitis /
- Pathology /
- Diagnosis

HTML全文

参考文献(11)

[1]	CHOWDHURY AB, MEHTA KJ. Liver biopsy for assessment of chronic liver diseases: A synopsis[J]. Clin Exp Med, 2023, 23( 2): 273- 285. DOI: 10.1007/s10238-022-00799-z.
[2]	KUBES P, JENNE C. Immune responses in the liver[J]. Annu Rev Immunol, 2018, 36: 247- 277. DOI: 10.1146/annurev-immunol-051116-052415.
[3]	COVELLI C, SACCHI D, SARCOGNATO S, et al. Pathology of autoimmune hepatitis[J]. Pathologica, 2021, 113( 3): 185- 193. DOI: 10.32074/1591-951X-241.
[4]	LOHSE AW, SEBODE M, BHATHAL PS, et al. Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology: Results of a workshop on AIH histology hosted by the European Reference Network on Hepatological Diseases and the European Society of Pathology[J]. Liver Int, 2022, 42( 5): 1058- 1069. DOI: 10.1111/liv.15217.
[5]	ZHANG X, JAIN D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis[J]. Hum Pathol, 2023, 132: 114- 125. DOI: 10.1016/j.humpath.2022.06.019.
[6]	LIU ZR, ZHU Y, XIE H, et al. Immune-mediated hepatitis induced by immune checkpoint inhibitors: Current updates and future perspectives[J]. Front Pharmacol, 2023, 13: 1077468. DOI: 10.3389/fphar.2022.1077468.
[7]	MURATORI L, LOHSE AW, LENZI M. Diagnosis and management of autoimmune hepatitis[J]. BMJ, 2023, 380: e070201. DOI: 10.1136/bmj-2022-070201.
[8]	ZEN Y. Autoimmune pancreatitis: Biopsy interpretation and differential diagnosis[J]. Semin Diagn Pathol, 2024, 41( 2): 79- 87. DOI: 10.1053/j.semdp.2024.01.001.
[9]	GUPTA R, NEYAZ A, CHOUGULE A, et al. Autoimmune pancreatitis type 2: Diagnostic utility of PD-L1 immunohistochemistry[J]. Am J Surg Pathol, 2019, 43( 7): 898- 906. DOI: 10.1097/PAS.0000000000001282.
[10]	KU YN, HONG SM, FUJIKURA K, et al. IL-8 expression in granulocytic epithelial lesions of idiopathic duct-centric pancreatitis(type 2 autoimmune pancreatitis)[J]. Am J Surg Pathol, 2017, 41( 8): 1129- 1138. DOI: 10.1097/PAS.0000000000000891.
[11]	SAYED AHMED A, ABREO M, THOMAS A, et al. Type 3 autoimmune pancreatitis(immune checkpoint inhibitor-induced pancreatitis)[J]. Curr Opin Gastroenterol, 2022, 38( 5): 516- 520. DOI: 10.1097/MOG.0000000000000873.