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Chinese expert consensus on the diagnosis and treatment of HIV co-infection with HBV and HCV
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Key words:
- HIV /
- Hepatitis B virus /
- Hepacivirus /
- Coinfection /
- Consensus
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表 1 目前我国主要的DAA方案
Table 1. Current major direct antiviral drug therapeutic regimens in China
类别 药品 规格 使用剂量 泛基因型方案 NS5B聚合酶核苷类似物抑制剂/NS5A抑制剂 SOF/VEL 400 mg SOF和100 mg VEL，复合片剂 1片，1次/d NS5A抑制剂+NS5B聚合酶核苷类似物抑制剂 CLP+SOF 60 mg CLP，胶囊 400 mg SOF，片剂 CLP 1粒，1次/d SOF 1片，1次/d NS5B聚合酶核苷类似物抑制剂/NS5A抑制剂/NS3/4A蛋白酶抑制剂 SOF/VEL/VOX 400 mg SOF、100 mg VEL、100 mg VOX，复合片剂 1片，1次/d 基因型特异性方案 NS3/4A蛋白酶抑制剂/NS5A抑制剂 EBR/GZR：适用于基因1b、4型 50 mg EBR和100 mg GZR，复合片剂 1片，1次/d NS5A抑制剂/NS5B聚合酶核苷类似物抑制剂 LDV/SOF：适用于基因1、2、4、5、6型 90 mg LDV和400 mg SOF，复合片剂 1片，1次/d NS5A抑制剂+NS3/4A蛋白酶抑制剂 RDV+DNV：适用于基因1b型 200 mg RDV，片剂 100 mg DNV，片剂 RDV 1片，1次/d DNV 1片，2次/d NS5A抑制剂+NS5B聚合酶核苷类似物抑制剂 EMV+SOF：适用于基因1b型 100 mg EMV，胶囊 400 mg SOF，片剂 EMV 1粒，1次/d SOF 1片，1次/d 
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表 2 部分DAA与cART药物的相互作用
Table 2. Interactions between some of the direct antiviral drugs and combined antiretroviral drugs
药物名称 ATV/c ATV/r DRV/c DRV/r LPV/r DOR EFV ETV NVP RPV FTR LEN MVC BIC CAB/RPV DTG EVG/c RAL TAF TDF SOF SOF/VEL SOF/VEL/VOX EBR/GZR LDV/SOF 注：绿色代表预计无临床意义的相互作用；红色代表不应当联合用药；橙色代表潜在临床意义上的相互作用，可能需要额外监测、改变药物剂量或安排管理时间；黄色代表潜在的相互作用，可能会弱化强度，不需要额外的监测或剂量调整。ATV/c，阿扎那韦/考比司他；ATV/r，阿扎那韦/利托那韦；DRV/c，达芦那韦/考比司他；DRV/r，达芦那韦/利托那韦；DOR，多拉韦林；FTR，fostemsavir；LEN，lenacapavir；MCV，马拉韦罗；BIC，比克替拉韦；CAB，卡替拉韦；DTG，多替拉韦；EVG/c，艾维雷韦/考比司他；RAL，拉替拉韦。
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