HBV相关慢加急性肝衰竭患者血清M30、M65检测及其临床意义

朱冰; 游绍莉; 万志红; 刘鸿凌; 荣义辉; 臧红; 张爱民; 辛绍杰

doi:10.3969/j.issn.1001-5256.2013.09.011

HBV相关慢加急性肝衰竭患者血清M30、M65检测及其临床意义

DOI: 10.3969/j.issn.1001-5256.2013.09.011

解放军第302医院肝衰竭诊疗与研究中心

基金项目:

解放军302医院院内课题资助项目(YNKT2012002)；

详细信息

中图分类号: R575.3
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出版历程
- 收稿日期: 2013-01-21
- 出版日期: 2013-09-20

Determination of serum M30 and M65 levels and its clinical significance in patients with HBV- related acute- on-chronic liver failure

Liver Failure Treatment and Research Center, 302 Hospital of PLA

Research funding:

摘要

摘要:
目的检测HBV相关慢加急性肝衰竭(ACLF)患者血清M30、M65的水平,探讨其与疾病的关系。方法选取31例HBV相关ACLF患者(好转20例,无效11例);20例慢性乙型肝炎(CHB)患者,10例健康人为对照,采用ELISA方法检测外周血清中M30、M65水平,多组间数据比较采用方差分析,两两比较采用q检验。结果 ACLF组血清M30[(508.65±340.16)U/L]、M65[(768.75±290.02)U/L]高于CHB组[(212.27±91.33)U/L,P<0.05;(384.40±134.46)U/L,P<0.05]和健康对照组[(94.12±17.64)U/L,P<0.05;(121.99±29.25)U/L,P<0.05]。ACLF患者血清M30与M65水平呈正相关(r=0.78,P<0.05)。好转组与无效组血清M30、M65水平差异无统计学意义[(572.38±349.45)vs(436.14±285.59)U/L,P=0.29;(817.25±307.66)vs(703.90±221.37)U/L,P=0.31]。结论 M30...
- 肝功能衰竭 /
- 肝炎,乙型,慢性 /
- 角蛋白18
Abstract:
Objective To determine the serum M30 and M65 levels in patients with HBV- related acute- on- chronic liver failure ( ACLF) and to investigate their association with this disease. Methods Thirty- one patients with HBV- related ACLF ( 20 cases with response to treatment and 11 cases without response to treatment) , 20 patients with chronic hepatitis B ( CHB) , and 10 healthy controls were enrolled in the study. Serum M65 and M30 levels were measured by enzyme- linked immunosorbent assay. Analysis of variance was used for comparison among groups; q- test was used for pairwise comparison. Results The serum M30 and M65 levels of ACLF patients ( 508. 65 ±340. 16 and 768. 75 ± 290. 02 U / L) were significantly higher than those of CHB patients ( 212. 27 ± 91. 33 and 384. 40 ± 134. 46 U / L) and healthy controls ( 94. 12 ± 17. 64 and 121. 99 ± 29. 25 U / L) ( P < 0. 05 for all comparisons) . In the ACLF patients, the serum level of M30was positively correlated with that of M65 ( r = 0. 78, P < 0. 05) ; no significant differences were seen between the cases with response to treatment and those without response to treatment in serum M30 and M65 levels ( 572. 38 ± 349. 45 vs 436. 14 ± 285. 59 U / L, P = 0. 29; 817. 25± 307. 66 vs 703. 90 ± 221. 37 U / L, P = 0. 31) . Conclusion Serum levels of M30 and M65 are sensitive indicators for the necrosis and apoptosis of hepatocytes. Significant increases in serum M30 and M65 levels are observed in patients with HBV- related ACLF.
- liver failure /
- hepatitis B, chronic /
- keratin-18

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参考文献(17)

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