声脉冲辐射力成像技术在非酒精性单纯性脂肪肝患者中的诊断价值

陈飞; 姚亚宁; 马苏美; 冯菲; 邹全; 薛丽丽

doi:10.3969/j.issn.1001-5256.2013.10.009

声脉冲辐射力成像技术在非酒精性单纯性脂肪肝患者中的诊断价值

DOI: 10.3969/j.issn.1001-5256.2013.10.009

兰州大学第一医院超声科

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中图分类号: R575.5
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出版历程
- 收稿日期: 2012-12-03
- 出版日期: 2013-10-20

Diagnostic value of acoustic radiation force impulse in patients with non- alcoholic simple fatty liver

Department of Ultrasound, The First Hospital of Lanzhou University

摘要

摘要:
目的探讨应用声辐射力脉冲成像（ARFI）技术评价非酒精性单纯性脂肪肝（NAFL）的价值。方法选取2011年6月-2011年12月本院收治的84例NAFL患者作为脂肪肝组,用二维超声分为轻、中、重度3组,并进行VTQ检测。同时选取36例健康人作为对照组,进行VTQ检测。比较对照组和脂肪肝组以及不同程度脂肪肝组内的差异。两组间比较采用t检验,多组间比较采用多因素方差分析,脂肪肝程度与VTQ值相关性采用Spearman秩相关检验。结果脂肪肝组与对照组间VTQ测值差异具有统计学意义[（1.74±0.49）m/s vs（1.18±0.22）m/s;t=3.436,P<0.01),不同程度脂肪肝组间VTQ测值差异具有统计学意义（F=21.266,P<0.01）,且随着患者脂肪肝程度的加重,肝脏的VTQ值逐渐增高,两者存在正相关（Spearman相关系数为0.542,P<0.001）。结论 ARFI技术能够反映NAFL的程度,可以用于门诊及体检中心对NAFL的筛查工作,可较准确的对NAFL进行定量评价。
- 弹性成像技术 /
- 脂肪肝 /
- 诊断
Abstract:
Objective To investigate the value of acoustic radiation force impulse ( ARFI) in evaluating non- alcoholic simple fatty liver ( NAFL) . Methods Eighty- four patients with NAFL, who were admitted to our hospital from June to December 2011, were divided into mild, moderate, and severe NAFL groups according to ultrasonographic findings. Meanwhile, 36 healthy people were chosen as the control group. Both groups were subjected to virtual touch tissue quantification ( VTQ) . Differences between the control group and NAFL groups and between the NAFL groups were determined. Comparisons between two groups were made using the t test and comparisons between multiple groups were conducted using the multi- factor analysis of variance. The correlation of fatty liver severity with VTQ was examined with the Spearman rank correlation test. Results The difference in VTQ value between the NAFL groups and control group was statistically significant ( 1. 74 ± 0. 49 m / s vs 1. 18 ± 0. 22 m / s; t = 3. 436, P < 0. 01) . VTQ values differed significantly across the NAFL groups ( F =21. 266, P < 0. 01) . With the increase in severity of fatty liver, VTQ value gradually increased, suggesting a positive correlation between the two variables ( Spearman correlation coefficient 0. 542, P < 0. 001) . Conclusion ARFI can reflect the severity of NAFL and can be used for the screening of patients with NAFL in outpatient and physical examination centers, offering an accurate quantitative tool for the evaluation of NAFL.
- elasticity imaging techniques /
- fatty liver /
- diagnosis

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参考文献(14)

[1]FAN JG, FARRELL GC.Epidemiology of non-alcoholic fatty liver disease in China[J].J Hepatol, 2009, 50 (1) :204-210.

[2]GAO GY, GU Q.Research advances in Chinese medical treatment of non-alcoholic fatty liver disease[J].J Changchun Univ Tradit Chin Med, 2012, 28 (2) :360-362. (in Chinese) 高广毅, 顾勤.非酒精性脂肪肝的中医药治疗研究进展[J].长春中医药大学学报, 2012, 28 (2) :360-362.

[3]EKSTEDT M, FRANZN LE, MATHIESEN UL, et al.Longterm follow-up of patients with NAFLD and elevated liver enzymes[J].Hepatology, 2006, 44 (4) :865-873.

[4]RAFIQ N, YOUNOSSI ZM.Nonalcoholic fatty liver disease:a practical approach to evaluation and management[J].Clin Liver Dis, 2009, 13 (2) :249-266.

[5]Group of Fatty Liver and Aloholic Liver Diseases, Society of Hepatology, Chinese Medical Association.Guidelines for management of non-alcoholic fatty liver disease[J].J Clin Hepatol, 2010, 26 (2) :120-124. (in Chinese) 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].临床肝胆病杂志, 2010, 26 (2) :120-124.

[6]WANG CZ, XU ZZ.Ultrasonography[M].Beijing:People's Medical Publishing House, 2001:229. (in Chinese) 王纯正, 徐智章.超声诊断学[M].北京:人民卫生出版社, 2001:229.

[7]XU HM, ZENG QY, CHEN ML, et al.An easy way to estimate the disgree of homogeneous fatty liver with ultrasonography[J].Chin J Interv Imaging Ther, 2008, 5 (2) :148-151. (in Chinese) 许惠敏, 曾庆玉, 陈麦林, 等.均匀性脂肪肝简易分度法探讨[J].中国介入影像与治疗学, 2008, 5 (2) :148-151.

[8]FAN JG.Non-alcoholic fatty liver disease:its past, present and future[J].Chin J Hepatol, 2007, 15 (9) :641-643. (in Chinese) 范建高.非酒精性脂肪性肝病的过去, 现在和将来[J].中华肝脏病杂志, 2007, 15 (9) :641-643.

[9]OPHIR J, CSPEDES I, PONNEKANTI H, et al.Elastography:a quantitative method for imaging the elasticity of biological tissues[J].Ultrason Imaging, 1991, 13 (2) :111-134.

[10]WANG MH, NIGHTINGALE KR.In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force[J].Ultrasound Med Biol, 2009, 35 (10) :1709-1721.

[11]LIU M, KONG XX, YANG P, et al.Effect of fibroblast growth factor-21 on lipid metabolism of nonalcoholic fatty liver disease cell model induced in vitro[J].J Jilin Univ:Med Edit, 2012, 38 (3) :477-481. (in Chinese) 刘敏, 孔祥鑫, 杨苹, 等.成纤维细胞生长因子-21对体外诱导的非酒精性脂肪肝细胞模型脂代谢的影响[J].吉林大学学报:医学版, 2012, 38 (3) :477-481.

[12]ZHANG DK, ZHAO YY, LI ZY, et al.The initial study of quantitative evaluation of the degree of non-alcoholic fatty liver disease by acoustic radiation force impulse imaging[J].J Clin Hepatol, 2011, 27 (5) :518-520. (in Chinese) 张大鹍, 赵媛媛, 李志艳, 等.非酒精性脂肪性肝病患者肝脏声辐射力脉冲成像的临床观察[J].临床肝胆病杂志, 2011, 27 (5) :518-520.

[13]LI YY, WANG XM, ZHANG YX, et al.The application value of score by ultrasound elastography at fatty fiver graduation[J].J Chin Clin Med Imaging, 2009, 20 (12) :911-913. (in Chinese) 李银燕, 王学梅, 张义侠, 等.超声弹性成像评分在脂肪肝分度中的应用价值[J].中国临床医学影像杂志, 2009, 20 (12) :911-913.

[14]FAN JG, WEI GH.Diagnosis of non-alcoholic fatty liver diseases[J].Chin J Hepatol, 2005, 13 (9) :710-711. (in Chinese) 范建高, 魏国华.非酒精性脂肪性肝病的诊断[J].中华肝脏病杂志, 2005, 13 (9) :710-711.

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