性激素对干细胞及干细胞治疗肝纤维化的影响

颜小明; 肖萍; 张立婷; 方雪琴; 骆菁怡; 李俊峰

doi:10.3969/j.issn.1001-5256.2014.01.024

性激素对干细胞及干细胞治疗肝纤维化的影响

DOI: 10.3969/j.issn.1001-5256.2014.01.024

兰州大学第一医院传染科

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中图分类号: R575.2
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出版历程
- 收稿日期: 2013-03-07
- 出版日期: 2014-01-20

Effects of sex hormones on stem cells and stem cell therapy for liver fibrosis

Department of Infectious Diseases, The First Hospital of Lanzhou University

摘要

摘要: 干细胞治疗肝纤维化已取得实质性进展,但是治疗中干细胞自我更新能力下降影响了疗效,因而提高干细胞自我更新能力尤为紧迫和重要,目前研究认为性激素对干细胞的自我更新能力有影响。以性激素作为切入点,综述了雌激素、雄激素对不同干细胞自我更新能力的影响及不同性别来源的干细胞功能上存在的差异,探讨了性激素对干细胞治疗肝纤维化的影响。认为性激素对将来干细胞治疗肝纤维化时提高干细胞自我更新能力,以及选择合适的细胞有重要的理论和临床价值。
- 肝硬化 /
- 干细胞 /
- 雌激素类 /
- 雄激素类
Abstract: Substantial progress has been made in the stem cell therapy for liver fibrosis. However, the therapeutic effect is limited by decreased self- renewal of stem cells during migration. Therefore, to improve the self- renewal of stem cells after transplantation is urgent and essential for the successful application of stem cells in clinical practice. Current studies have shown that sex hormones have an impact on the self- renewal of stem cells. The effects of estrogens and androgens on the self- renewal of various stem cells and the functional differences between the stem cells from persons of different sexes are reviewed. Moreover, the effect of sex hormones on stem cell therapy for liver fibrosis is discussed. It is considered that sex hormones have significant theoretical and clinical values for improving the self- renewal of stem cells and selecting appropriate stem cells in the stem cell therapy for liver fibrosis.
- liver cirrhosis /
- stem cells /
- estrogens /
- androgens

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参考文献(36)

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