Changes in peripheral plasma concentrations of macrophage migration inhibitory factor,interleukin-17,and interleukin-10 and their correlations with HBV DNA load in chronic HBV carriers
-
摘要: 目的探讨HBV携带者外周血巨噬细胞移动抑制因子(MIF)、白细胞介素(IL)17和IL-10水平变化,及其与肝功能水平和HBV DNA定量的相关性。方法收集2012年2月-2013年12月于兰州市第二人民医院就诊的60例HBV携带者空腹血清样本,其中慢性HBV携带者39例,非活动性HBs Ag携带者21例;采用ELISA法检测血清细胞因子MIF、IL-17和IL-10水平;采用荧光定量PCR法测定各组HBV DNA定量,应用全自动生化分析仪检测血清肝功能水平,进行临床相关性分析。同期50例健康体检者为对照组。计量资料组间比较采用配对t检验,相关性比较采用Pearson相关分析。结果与健康对照组相比,慢性HBV携带者组和非活动性HBs Ag携带者组外周血MIF、IL-17和IL-10水平均显著升高,差异有统计学意义(t值分别为4.50,3.11,9.99;6.28,4.11,14.96;P值均<0.01),其中慢性HBV携带者组MIF、IL-17和IL-10水平低于非活动性HBs Ag携带者组,但差异无统计学意义(P值均>0.05)。慢性HBV携带者中中病毒载量组患者MIF和...
-
关键词:
- 肝炎病毒,乙型 /
- 巨噬细胞游走抑制因子 /
- 白细胞介素17 /
- 白细胞介素10
Abstract: Objective To determine the changes in peripheral plasma concentrations of macrophage migration inhibitory factor(MIF),interleukin-17(IL-17),and interleukin-10(IL-10) in HBV carriers and their correlations with liver function or HBV DNA load of HBV carriers.Methods Fasting plasma samples were collected from 60 HBV carriers who were treated at the Second People's Hospital of Lanzhou from February 2012 to December 2013,including 39 chronic HBV carriers and 21 inactive HBs Ag carriers.The plasma concentrations of MIF,IL-17,and IL-10 were determined using ELISA.HBV DNA load was measured by quantitative real-time PCR.Liver function was tested using an automatic biochemical analyzer.Fifty healthy subjects served as controls.Continuous data were compared using the paired t test.Correlation analysis was performed using the Pearson correlation test.Results Compared with those in healthy controls,plasma MIF,IL-17,and IL-10 levels in chronic HBV carriers and inactive HBs Ag carriers increased significantly(t = 4.50,3.11,and9.99; 6.28,4.11,and 14.96; all P < 0.01).Plasma MIF,IL-17,and IL-10 levels in chronic HBV carriers were lower than those in inactive HBs Ag carriers,though not reaching statistical significance(P > 0.05).In chronic HBV carriers with different HBV DNA levels,we found that carriers with medium HBV DNA levels had lower MIF and IL-17 levels,but higher IL-10 levels,though the differences were not statistically significant(P > 0.05).There were no correlations between peripheral plasma levels of cytokines(MIF,IL-17,and IL-10) and liver function(ALT,AST,TBil,and Alb) or HBV DNA load(all P > 0.05).Conclusion MIF,IL-17,and IL-10 may play an important role in chronic HBV infection,and plasma levels of MIF,IL-17,and IL-10 can be used as important indicators to assess the severity of chronic hepatitis B in HBV carriers.
本文二维码
计量
- 文章访问数: 2336
- HTML全文浏览量: 14
- PDF下载量: 460
- 被引次数: 0