Levels and clinical significance of serum 25-hydroxy vitamin D in patients with chronic liver disease
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摘要:
目的探讨慢性肝病患者血清25-羟维生素D[25(OH)D]水平及其临床意义。方法收集2012年6月-2013年9月吉林大学第一医院肝胆胰内科153例慢性肝病住院患者的血清作为试验组,应用液相色谱串联质谱检测技术检测患者的25(OH)D水平,以同院体检中心300例健康人作对照组。试验组分为非肝硬化组、肝硬化组(Child-Pugh A、B、C级)及原发性胆汁性肝硬化(PBC)组,分析比较各组间的差异,计量资料采用t检验和方差分析,计数资料采用χ2检验,各变量间相关性采用Pearson直线相关分析。结果 153例慢性肝病患者正常(≥30 ng/ml)、不足(2030 ng/ml)、缺乏(1020 ng/ml)及严重缺乏(<10 ng/ml)的比例分别为20.3%、22.9%、35.9%、20.9%。肝硬化组25(OH)D缺乏及严重缺乏的比例(41.7%、25.0%)明显多于非肝硬化组(27.5%、12.5%)及PBC组(23.5%、17.6%),差异均有统计学意义(χ2=6.26118.474,P=0.001...
Abstract:Objective To investigate the levels and clinical significance of serum 25-hydroxy vitamin D[25(OH) D] in patients with chronic liver disease.Methods A total of 153 hospitalized patients with chronic liver disease in the First Affiliated Hospital of Jilin University from June 2012 to September 2013 were enrolled in the study group.The levels of serum 25(OH) D were measured by liquid chromatography tandem mass spectrometry.The serum samples from 300 healthy volunteers who underwent physical examination in our hospital were used as controls.The study group was divided into three subgroups: non-cirrhosis,liver cirrhosis [Child-Pugh(CP) grades A,B,and C],and primary biliary cirrhosis.Comparison of continuous data between groups was made by t test and analysis of variance,and comparison of categorical data was made by chi-square test.Correlation between different variables was investigated by Pearson linear regression analysis.Results Of the 153 patients with chronic liver disease,the percentages of those who had vitamin D adequacy(≥30 ng / ml),insufficiency(20-30 ng / ml),deficiency(10-20 ng / ml),and severe deficiency(< 10 ng / ml) were 20.3%,22.9%,35.9%,and20.9%,respectively.The percentages of patients with vitamin D deficiency and severe deficiency were significantly higher in the cirrhosis subgroup than in the non-cirrhosis and primary biliary cirrhosis subgroups(41.7%,25.0% vs 27.5%,12.5% and 23.5%,17.6%,respectively; χ2= 6.261-18.474,P = 0.001-0.012).The serum 25(OH) D levels in patients with cirrhosis were significantly lower compared with those in patients without cirrhosis and in controls(18.58 ± 12.48 vs 23.78 ± 11.81 and 25.69 ± 12.39 ng / ml,P = 0.029 and0.001).CP class C cirrhotic patients had significantly lower serum levels of 25(OH) D compared with CP class A patients(P = 0.009).Conclusion Serum 25(OH) D deficiency is common in patients with chronic liver disease.25(OH) D levels in cirrhotic patients,especially in CP class C patients,are markedly lower than those in non-cirrhotic patients.
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Key words:
- liver diseases /
- vitamin D deficiency
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