A study of the relationship between EBV DNA and EBV antibody levels
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摘要:
目的分析EB病毒(EBV)抗体及EBV DNA的影响因素及关联性。方法回顾性分析2014年1-9月在北京大学第一医院就诊的143例患者的年龄、性别、血常规、肝功能、EBV抗体及DNA检查结果,用Spearman相关性分析对EBV抗体及EBV DNA的相关影响因素进行分析,多个独立样本间比较使用Kruskal-Wallis H检验,独立样本间两两比较使用Mann-Whitney U检验。结果血清EBV DNA(r=0.1690.693,P<0.05)、EBV-VCA-Ig M(r=0.1530.434,P<0.05)均与外周血淋巴细胞EBV DNA、ALT、AST、ALP、GGT、白细胞(WBC)及异形淋巴细胞呈正相关,并且两者也呈正相关(r=0.434,P=0.00);外周血淋巴细胞EBV DNA与血清EBV DNA、EBV-VCA-Ig M、AST、ALP、WBC及异形淋巴细胞呈正相关(r=0.2070.693,P<0.05)。外周血淋巴细胞EBV DNA阳性率70.6%(101/143),血清EBV...
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关键词:
- 爱泼斯坦巴尔病毒感染 /
- EBV DNA
Abstract:Objective To study the relationship between Epstein-Barr virus(EBV) DNA and EBV antibody levels.Methods A retrospective study was conducted on 143 patients who underwent EBV DNA testing in serum and lymphocytes from January to August,2014.The clinical data,including age,sex,blood routine and biochemical examination,serum / lymphocyte EBV DNA,EBV-VCA-Ig M,and EBV-VCA-Ig G were recorded.Spearman correlation analysis was used to measure the degree of the relationships.Kruskal-Wallis H test or Mann-Whitney U test were applied to compare the differences between three or two groups.Results The spearman rank correlation coefficient between serum EBV DNA and EBV-VCA-Ig M levels was 0.434(P = 0.00),while the correlation coefficients of serum EBV DNA level and EBV-VCA-Ig M level with lymphocyte EBV DNA,alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),gamma-glutamyl transpeptidase(GGT),white blood cells(WBC),and heterotypic lymphocytes ranged from0.169 to 0.693(P < 0.05) and from 0.153 to 0.434(P < 0.05),respectively.The spearman rank correlation coefficient of lymphocyte EBV DNA with serum EBV DNA,EBV-VCA-Ig M,AST,ALP,WBC,and heterotypic lymphocytes ranged from 0.207 to 0.693(P <0.05).The positive rates of EBV DNA in lymphocytes and serum were 70.6%(101 /143) and 32.2%(46 /143),respectively.The EBV-VCA-Ig M positive rate was 22.4%(32 /143),and 22.5%(25 /111) of the patients with negative EBV-VCA-Ig M were positive for serum EBV DNA.The overall positive rate for EBV-VCA-Ig G was 91.6%(131 /143).The EBV-VCA-Ig M positive rate in patients with positive serum EBV DNA(21 /46,45.7%) was significantly higher than that in patients with positive lymphocyte EBV DNA(29 /101,28.7%)(χ2= 7.95,P < 0.01).Conclusion Serum EBV DNA level is strongly correlated with EBV-VCA-Ig M level.Moreover,serum EBV DNA exhibits a higher positive rate than EBV-VCA-Ig M.Simultaneous detection of serum EBV DNA and EBV-VCA-Ig M may benefit the diagnosis of current EBV infection.
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Key words:
- Epstein-Barr virus infections /
- EBV DNA
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