Research advances in micro RNAs in regulating hepatitis C virus replication and antiviral therapy
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摘要: HCV感染是导致慢性肝炎、肝硬化及肝细胞癌(HCC)的主要原因之一。微小RNA(miRNAs)是一类非编码小分子RNA,可参与人体多种生理、病理过程。简述了mi RNAs调控HCV复制的机制,探讨了肝特异性microRNA-122(mi R-122)拮抗剂对丙型肝炎抗病毒治疗的作用。认为miRNAs对HCV的表达起着重要调节作用,有望成为治疗HCV感染的一种措施,但仍需进一步研究。Abstract: Hepatitis C virus(HCV) infection is one of the most common causes of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma.Micro RNAs(mi RNAs),a class of small,non-coding RNA,are involved in a variety of physiological and pathological processes in human bodies.The mechanism by which miRNAs regulate HCV replication is described,and the effects of liver-specific micro RNA-122 antagonists on hepatitis C antiviral therapy are discussed.Our study indicates that miRNAs play an important regulatory role in HCV expression.Targeting miRNAs may be a potential therapeutic approach for treating HCV infection,but further studies are still in need.
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Key words:
- hepacivirus /
- micro RNA /
- antiviral agents /
- review
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