Relationship between chronic hepatitis C virus genotype and thyroid function
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摘要:
目的初步探讨慢性丙型肝炎(CHC)2a、1b基因型与甲状腺激素水平及甲状腺自身抗体的关系。方法收集2013年10月-2014年12月在西安交通大学医学院第二附属医院就诊及住院的CHC患者196例,采用RT-PCR法对患者进行HCV基因型的检测,使用化学发光免疫分析法检测甲状腺激素水平及甲状腺自身抗体水平,并对基因型与甲状腺功能的关系进行分析。计量资料组间比较采用t检验,相关危险因素采用Logistic回归分析。结果 196例丙型肝炎患者,HCV-2a型占57.7%(113例),HCV-1b型占42.3%(83例)。对HCV-2a型、HCV-1b型患者甲状腺激素水平、甲状腺自身抗体水平比较,差异均无统计学意义(P值均>0.05);其中92例HCV患者使用干扰素治疗,甲状腺激素水平、甲状腺自身抗体水平在HCV-2a型、HCV-1b型中差异均无统计学意义(P值均>0.05)。多元Logistic回归分析显示,基因分型不是甲状腺自身抗体异常的危险因素(比值比为2.012,P>0.05)。结论 CHC基因分型与甲状腺功能无明显内在联系,基因分型对甲状腺功能无明显影响。
Abstract:Objective To preliminarily investigate the relationship between the chronic hepatitis C virus( HCV) genotypes,2a and 1b,and thyroid hormone levels and autoantibodies. Methods In patients who were admitted to our hospital and diagnosed with chronic hepatitis C from October 2013 to December 2014,reverse transcription- polymerase chain reaction was performed to determine the HCV genotype. A total of 196 patients with HCV genotype 2a or 1b were enrolled as subjects. The levels of thyroid hormone and thyroid autoantibodies were determined by chemiluminescence immunoassay,and the relationship between the HCV genotype and thyroid function was analyzed. Between- group comparison of continuous data was performed by t test,and the risk factors were evaluated by logistic regression analysis. Results In the 196 patients with hepatitis C,57. 7%( n = 113) were infected with HCV- 2a,and 42. 3%( n = 83) were infected with HCV- 1b.There were no significant differences in levels of thyroid hormone and thyroid autoantibodies between patients with HCV- 2a and HCV- 1b( P > 0. 05). In the 92 patients who were treated with interferon,there were no significant differences in levels of thyroid hormone and thyroid autoantibodies between patients with HCV- 2a and HCV- 1b( P > 0. 05). Logistic regression analysis showed that the genotype classification was not a risk factor for abnormal thyroid autoantibodies( OR = 2. 012,P > 0. 05). Conclusion There is no intrinsic link between chronic HCV genotype classification and thyroid function. The genotype classification has no substantial effect on thyroid function.
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Key words:
- hepatitis C,chronic /
- genotype /
- thyroid function tests /
- autoantibodies
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