Efficacy of terlipressin therapy for refractory ascites in cirrhosis and type-2 hepatorenal syndrome
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摘要:
目的观察特利加压素治疗肝硬化顽固性腹水合并Ⅱ型肝肾综合征(HRS)的疗效。方法选取2009年6月-2014年6月于湖北医药学院附属人民医院住院的40例肝硬化顽固性腹水合并Ⅱ型HRS患者,将其分为治疗组(23例)和对照组(17例)。对照组给予护肝、抗感染、利尿、营养支持等内科综合治疗,治疗组在对照组基础上给予特利加压素治疗,观察两组治疗前后体质量、腹围、24 h尿量及尿钠、肝肾功能及药物不良反应等。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果治疗结束后,治疗组24 h尿量和尿钠由治疗前(270.0±120.0)ml和(20.6±10.5)mmol增加到治疗后(1200.0±490.0)ml和(62.5±16.5)mmol;体质量和腹围由治疗前(58.5±5.3)kg和(97.6±7.5)cm减少到治疗后(53.6±4.8)kg和(90.5±6.8)cm;ALT、TBil、尿素氮(BUN)、血肌酐(Cr)较治疗前明显下降,白蛋白(Alb)较治疗前明显升高,差异均有统计学意义(t值为3.765.57,P值均<0.05)。两组治疗后比较,治疗组上述...
Abstract:Objective To explore the efficacy of terlipressin therapy for refractory ascites in cirrhosis and type- 2 hepatorenal syndrome( HRS- 2). Methods Forty patients with refractory ascites in cirrhosis and HRS- 2 who were admitted to our hospital from June 2009 to June 2014 were randomly divided into treatment group( n = 23) and control group( n = 17). The control group was given comprehensive medical treatment including liver protection therapy,anti- infection therapy,and nutritional support,and the treatment group was treated with terlipressin in addition to the treatment for the control group. The body weight,abdomen circumference,urine volume and urinary sodium output within 24 hours,liver and kidney function,and adverse reactions in both groups were evaluated before and after treatment. Between- group comparison of continuous data was performed by t test,and between- group comparison of categorical data was performed byχ2test. Results In the treatment group,the urine volume and urinary sodium output within 24 hours were significantly increased after treatment( 270. 0 ± 120. 0 vs 1200. 0 ± 490. 0 ml,P < 0. 05; 20. 6 ± 10. 5 vs 62. 5 ± 16. 5 mmol,P < 0. 05),while the body weight and abdomen circumference were significantly reduced after treatment( 58. 5 ± 5. 3 vs 53. 6 ± 4. 8 kg,P < 0. 05; 97. 6 ± 7. 5 vs 90. 5 ± 6. 8 cm,P <0. 05). The serum levels of alanine aminotransferase,total bilirubin,blood urea nitrogen,and creatinine in the treatment group were significantly lower after treatment( P < 0. 05),while the serum level of Alb in the treatment group was significantly higher after treatment( P <0. 05). All the above indices were significantly superior in the treatment group than in the control group( P < 0. 05). The overall response rate in the treatment group was significantly higher than that in the control group( 82. 6% vs 52. 9%,P < 0. 05). There were no severe adverse reactions in both groups. Conclusion On the basis of comprehensive medical treatment,terlipressin achieves good efficacy in the treatment of refractory ascites in cirrhosis and HRS- 2 with few adverse reactions.
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Key words:
- liver cirrhosis /
- ascites /
- hepatorenal syndrome /
- terlipressin
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