Expression and significance of Bax, COX2, and ID1 in gallbladder adenocarcinoma
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摘要:
目的探讨Bax、环氧合酶(COX)2和DNA结合抑制因子(ID)1蛋白在胆囊腺癌组织中的表达及意义。方法收集2000-2013年在兰州大学第一医院病理科经病理检查证实胆囊腺癌标本70例,另取20例高级别上皮内瘤变、30例低级别上皮内瘤变及20例胆囊炎症标本作为对照。采用免疫组织化学SP法对4组进行Bax、COX2和ID1蛋白检测。采用四格表的精确概率法,对相应数据进行χ2检验,Bax、COX2和ID1之间相关性应用Spearman相关分析,生存数据应用Kapan-Meier生存分析。结果腺癌的Bax表达分别与高级别上皮内瘤变、低级别上皮内瘤变、炎症组织比较,差异均有统计学意义(P值均<0.05);腺癌的COX2和ID1表达分别与低级别上皮内瘤变、炎症组织比较,差异均有统计学意义(P值均<0.05);高级别上皮内瘤变分别与低级别上皮内瘤变、炎症组织比较,差异均有统计学意义(P值均<0.05)。高分化胆囊腺癌中Bax阳性率显著高于中、低分化组织,差异有统计学意义(P=0.001)。COX2和ID1在Nevin分期ⅠⅢ期组织中阳性率显著高于Ⅳ...
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关键词:
- 胆囊肿瘤 /
- 腺癌 /
- bc1-2相关X蛋白质 /
- 环氧化酶2 /
- DNA结合蛋白质类
Abstract:Objective To investigate the expression and significance of Bax,cyclooxygenase- 2( COX2),and inhibitor of differentiation 1( ID1) in gallbladder adenocarcinoma tissues. Methods A total of 70 patients confirmed with gallbladder adenocarcinoma by pathological examination in the Department of Pathology,The First Hospital of Lanzhou University,from 2000 to 2013 were collected. Besides,20 cases of high- grade intraepithelial neoplasia,30 cases of low- grade intraepithelial neoplasia,and 20 cases of cholecystitis were selected as controls. The protein expression of Bax,COX2,and ID1 in the four groups was determined using the immunohistochemical SP method. Meanwhile,chi- square test was conducted on the data using fourfold table exact test,the correlations between Bax,COX2,and ID1 were determined by Spearman correlation analysis,and survival data were subjected to Kapan- Meier survival analysis. Results The high- grade intraepithelial neoplasia group,low- grade intraepithelial neoplasia group,and cholecystitis group showed significantly different expression of Bax compared with the gallbladder adenocarcinoma group( all P < 0. 05); the low- grade intraepithelial neoplasia group and cholecystitis group showed significantly different expression of COX2 and ID1 compared with the gallbladder adenocarcinoma group( all P < 0. 05); the high- grade intraepithelial neoplasia group showed significantly different expression of COX2 and ID1 compared with low- grade intraepithelial neoplasia group and cholecystitis group( all P < 0. 05). Survival analysis showed that patients with positive Bax had a significantly higher survival rate than those with positive COX2 and ID1( both P < 0. 05). COX2 was positively correlated with ID1( r = 0. 329,P < 0. 05).Conclusion Bax,COX2,and ID1 may play a role in the development of gallbladder adenocarcinoma,and joint detection of Bax,COX2,and ID1 is of great significance for the prognosis of gallbladder adenocarcinoma.
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