Effect of non-bioartificial liver support system on serum manganese levels in patients with hepatic encephalopathy
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摘要:
目的探讨非生物型人工肝血浆置换疗法对肝性脑病患者血锰水平的影响及其临床意义。方法以2007年10月-2011年7月于广西医科大学第一附属医院住院的22例肝性脑病患者为研究对象,给予血浆置换治疗,根据研究对象预后不同分为好转组和恶化组。采用石墨炉原子吸收法动态测定血中锰含量,分析治疗前后及病情转变后患者血锰水平的变化情况。计量资料组间比较采用t检验,并采用Pearson相关分析。结果 22例患者治疗后血锰水平(22.6±6.9)μg/L均较治疗前(36.4±10.6)μg/L下降,差异有统计学意义(t=4.789,P=0.000)。治疗后,8例好转,14例恶化,好转组血锰水平(18.9±6.3)μg/L明显低于恶化组的血锰水平(39.2±9.8)μg/L,差异有统计学意义(t=4.816,P=0.000)。结论非生物型人工肝支持可以降低肝性脑病患者血锰水平;血锰水平可能影响慢性肝性脑病患者的病情发展。
Abstract:Objective To investigate the effect of plasma exchange with non- bioartificial liver support system on serum manganese levels in patients with hepatic encephalopathy and its clinical significance. Methods A total of 22 inpatients with hepatic encephalopathy who were admitted to our hospital from October 2007 to July 2011 were treated with plasma exchange,and were divided into improvement group and aggravation group based on prognosis. The serum manganese level was dynamically determined using graphite furnace atomic absorption spectrophotometry,and the changes in manganese levels after treatment and relief or worsening of disease were analyzed. Comparison between the two groups was made using t test. Results After treatment,the 22 patients all showed significantly reduced manganese levels( 22. 6 ± 6. 9μg /L vs 36. 4 ± 10. 6 μg /L,t = 4. 789,P = 0. 000). After treatment,8 cases improved and 14 cases aggravated,and the improvement group showed a significantly lower manganese level than the aggravation group( 18. 9 ± 6. 3 μg / L vs 39. 2 ± 9. 8 μg / L,t = 4. 816,P =0. 000). Conclusion Non- bioartificial liver support system can reduce serum manganese levels in patients with hepatic encephalopathy,and the serum manganese level may influence the disease progression.
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Key words:
- hepatic encephalopathy /
- plasma exchange /
- manganese
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