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重组人血管内皮抑制素联合肝动脉介入治疗对中晚期肝癌无疾病进展生存期的影响

郝明志 林海澜 陈起忠 胡育斌

郝明志, 林海澜, 陈起忠, 胡育斌. 重组人血管内皮抑制素联合肝动脉介入治疗对中晚期肝癌无疾病进展生存期的影响[J]. 临床肝胆病杂志, 2016, 32(1): 92-96. DOI: 10.3969/j.issn.1001-5256.2016.01.016.
引用本文: 郝明志, 林海澜, 陈起忠, 胡育斌. 重组人血管内皮抑制素联合肝动脉介入治疗对中晚期肝癌无疾病进展生存期的影响[J]. 临床肝胆病杂志, 2016, 32(1): 92-96. DOI: 10.3969/j.issn.1001-5256.2016.01.016.
Hao MingZhi, Lin HaiLan, Chen QiZhong, Hu YuBin. Effect of recombinant human endostatin combined with hepatic artery interventional therapy on progression-free survival of patients with advanced hepatocellular carcinoma[J]. J Clin Hepatol, 2016, 32(1): 92-96. DOI: 10.3969/j.issn.1001-5256.2016.01.016.
Citation: Hao MingZhi, Lin HaiLan, Chen QiZhong, Hu YuBin. Effect of recombinant human endostatin combined with hepatic artery interventional therapy on progression-free survival of patients with advanced hepatocellular carcinoma[J]. J Clin Hepatol, 2016, 32(1): 92-96. DOI: 10.3969/j.issn.1001-5256.2016.01.016.

重组人血管内皮抑制素联合肝动脉介入治疗对中晚期肝癌无疾病进展生存期的影响

DOI: 10.3969/j.issn.1001-5256.2016.01.016
详细信息
  • 中图分类号: R735.7

Effect of recombinant human endostatin combined with hepatic artery interventional therapy on progression-free survival of patients with advanced hepatocellular carcinoma

  • 摘要:

    目的观察重组人血管内皮抑制素(恩度)联合肝动脉介入治疗对中晚期肝癌无疾病进展生存期的影响。方法选取2011年3月-2015年5月福建省肿瘤医院收治的86例中晚期肝癌患者,按照配对设计分为治疗组和对照组。治疗组(n=43)采用恩度联合肝动脉介入治疗;对照组(n=43)采用肝动脉介入治疗联合口服中药肝复乐。计数资料组间比较采用χ2检验,计量资料组间比较采用t检验。Kaplan-Meier法进行生存分析,单因素分析采用Log-rank法,多因素回归分析采用Cox比例风险模型。结果治疗组和对照组的中位无疾病进展生存期分别为154 d[95%可信区间(95%CI):94214 d]、70 d(95%CI:39101 d),两组比较差异具有统计学意义(χ2=10.741,P=0.001)。单因素分析显示,肝硬化严重程度、肿瘤个数、门静脉主干癌栓/下腔静脉癌栓是中晚期肝癌患者预后的影响因素(χ2值分别为8.182、9.150、6.565,P值分别为0.004、0.027、0.038);多因素分析显示,肝硬化严重程度、门静脉主干癌栓/下腔静脉癌栓是恩度联合肝...

     

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  • 收稿日期:  2015-10-19
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