全身化疗联合经肝动脉化疗栓塞术治疗乳腺癌肝转移的疗效观察

李立业

doi:10.3969/j.issn.1001-5256.2016.01.017

全身化疗联合经肝动脉化疗栓塞术治疗乳腺癌肝转移的疗效观察

DOI: 10.3969/j.issn.1001-5256.2016.01.017

李立业

山东省医学科学院附属医院外一科

详细信息

中图分类号: R737.9
计量
- 文章访问数: 2553
- HTML全文浏览量: 45
- PDF下载量: 409
- 被引次数: 0
出版历程
- 收稿日期: 2015-09-02
- 出版日期: 2016-01-20

Clinical effect of systemic chemotherapy combined with transcatheter arterial chemoembolization in treatment of breast cancer with liver metastases

Li LiYe

First Department of Surgery,Affiliated Hospital of Shandong Academy of Medical Sciences

摘要

摘要:
目的探讨发生肝转移的乳腺癌患者采用全身化疗联合经肝动脉化疗栓塞术（TACE）治疗的效果。方法选取2012年12月-2014年12月于山东省医学科学院附属医院接受治疗的乳腺癌并发肝转移女性患者86例,将其平均分为试验组和对照组。对照组采用全身化疗,试验组给予全身化疗基础上联合TACE治疗,比较2组临床疗效、病灶变化情况以及治疗后患者生活质量评分情况。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果试验组患者治疗的总有效率高于对照组,差异有统计学意义（90.70%vs 58.14%,χ2=13.07,P=0.001）;与对照组相比,试验组患者治疗后肿瘤直径、淋巴结直径较小,差异均有统计学意义（t值分别为4.26、4.63,P值均<0.001）;试验组患者治疗后3、6个月生活质量评分均高于对照组,差异均有统计学意义（t值分别为6.30、3.89,P值均<0.001）。结论对乳腺癌肝转移患者采用全身化疗联合TACE治疗的效果显著,能够改善患者症状,减少药物不良反应,提高生活质量,且安全可靠,值得推广应用。
- 乳腺肿瘤 /
- 肿瘤转移 /
- 药物疗法 /
- 化学栓塞,治疗性
Abstract:
Objective To investigate the clinical effect of systemic chemotherapy combined with transcatheter arterial chemoembolization( TACE) in the treatment of breast cancer with liver metastases. Methods A total of 86 female breast cancer patients with liver metastases who were treated in the Affiliated Hospital of Shandong Academy of Medical Sciences from December 2012 to December 2014 were selected and equally divided into experimental group and control group. The patients in the control group received systemic chemotherapy,and those in the experimental group received systemic chemotherapy combined with TACE. The clinical effect,changes in lesions,and patients' quality of life( QOL) scores after treatment were compared between two groups. The t- test was applied for comparison of continuous data between the two groups,and the chi- square test was applied for comparison of categorical data between the two groups. Results The experimental group had a significantly higher overall response rate than the control group( 90. 70% vs 58. 14%,χ2= 13. 07,P = 0. 001). Compared with the control group,the experimental group had significantly smaller diameters of tumors and lymph nodes after treatment( t = 4. 26 and 4. 63,both P < 0. 001),as well as significantly higher QOL scores at 3 and 6 months after treatment( t = 6. 30 and 3. 89,both P <0. 001). Conclusion Systemic chemotherapy combined with TACE has a significant therapeutic effect in breast cancer patients with liver metastases,and can improve patients' symptoms,reduce adverse drug reactions,and improve QOL. As a safe and reliable therapeutic method,it is worthy of clinical application.
- breast neoplasms /
- neoplasm metastasis /
- drug therapy /
- chemoembolization,therapeutic

HTML全文

参考文献(16)

[1]RAO ZG,GAO JF,ZHANG BC,et al.Clinical observation of breast cancer liver metastasis after mastectomy by combined treatment of transarterial chemoembolization(TACE)and systemic chemotherapy[J].J Mod Oncol,2013,21(9):1994-1996.(in Chinese)饶智国,高建飞,章必成,等.全身化疗联合肝动脉栓塞化疗治疗乳腺癌术后肝转移的临床疗效观察[J].现代肿瘤医学,2013,21(9):1994-1996.

[2]WALKER MS,HASAN M,YIM YM,et al.Retrospective study of the effect of disease progression on patient reported outcomes in HER-2negative metastatic breast cancer patients[J].Health Qual Life Outcomes,2011,9:46.

[3]ZHANG P,XU EJ,HUANG Y,et al.Curative effect of radiofrequency ablation combined with chemotherapy for liver metastases from breast cancer in 6 cases[J/CD].Chin J Hepatic Surg:Electronic Edition,2014,3(5):299-302.(in Chinese)张鹏,许尔蛟,黄勇,等.射频消融联合化疗治疗乳腺癌肝转移六例疗效分析[J/CD].中华肝脏外科手术学电子杂志,2014,3(5):299-302.

[4]AARONSON NK,AHMEDZAI S,BERGMAN B,et al.The European Organization for research and treatment of cancer QLQ-C30:a quality-of-life instrument for use in international clinical trials in oncology[J].J Natl Cancer Inst,1993,85(5):365-376.

[5]LIU CF,YAN JJ,LI J,et al.Partial hepatectomy for liver metastases from breast cancer:a retrospective study of 47 patients[J].Chin J Hepatobiliary Surg,2012,18(6):420-423.(in Chinese)刘才峰,晏建军,李静,等.乳腺癌术后肝脏转移的手术治疗:47例回顾性分析[J].中华肝胆外科杂志,2012,18(6):420-423.

[6]DONG Y,KANG LH,GUAN M,et al.Clinical effect and influencing factor analysis of postoperative adjurant therapy for patients with breast cancer[J].J Jilin Univ:Med Edit,2015,41(3):636-642.(in Chinese)董营,康丽花,关萌,等.乳腺癌患者术后辅助治疗的临床效果及其影响因素分析[J].吉林大学学报:医学版,2015,41(3):636-642.

[7]LALISANG RI,ERDKAMP FL,RODENBURG CJ.Epirubicin and paclitaxel with G-CSF support in first line metastatic breast cancer:a randomized phaseⅡstudy of dose-dense and dose-escalated chemotherapy[J].Breast Cancer Res Treat,2011,128(2):437-445.

[8]MIN WL,WANG XJ,LIU XX,et al.Diagnosis and treatment of39 cases of breast cancer patients with liver metastases[J].J Mod Oncol,2014,22(7):1592-1594.(in Chinese)闵卫利,王西京,刘小旭,等.39例乳腺癌并肝转移诊治体会[J].现代肿瘤医学,2014,22(7):1592-1594.

[9]WU QC.Effect comparison of different chemotherapy regimens of capecitabine in breast cancer liver metastasis[J].China Modern Med,2015,22(11):63-65.(in Chinese)吴庆成.卡培他滨不同化疗方案治疗乳腺癌肝转移的效果对比[J].中国当代医药,2015,22(11):63-65.

[10]XIE J,CHEN RP,ZHANG YF,et al.The clinical effects of navelbine plus platinum chemotherapy on recurrent metastatic breast cancer of elderly patients[J].Anti-Tumor Pharm,2015,5(3):209-212.(in Chinese)夏金,陈瑞萍,张彦芳,等.诺维本联合铂类二线化疗治疗老年复发转移性乳腺癌的疗效分析[J].肿瘤药学,2015,5(3):209-212.

[11]ZHAO ZB.Surgical treatment for patients with liver metastasis after breast cancer surgery[J].Zhejiang Clin Med J,2012,14(3):268-270.(in Chinese)赵宗彬.乳腺癌术后肝转移患者的手术治疗分析[J].浙江临床医学,2012,14(3):268-270.

[12]TSIMBERIDOU AM,LETOURNEAU K,FU S,et al.PhaseⅠclinical trial of hepatic arterial infusion of paclitaxel in patients with advanced cancer and dominant liver involvement[J].Cancer Chemother Pharmacol,2011,68(1):247-253.

[13]ZHAO ZB,JIAN ZY.The Retrospective analysis of the treatment for alone hepatic metastatic breast carcinoma not suitable for excision after the primary lesion removal[J].J Hubei Univ Med,2012,31(3):204-208.(in Chinese)赵宗彬,菅志远.无法手术切除的乳腺癌单纯性肝转移患者治疗的回顾性分析[J].湖北医药学院学报,2012,31(3):204-208.

[14]CHEN YL,WANG YF,LIU K,et al.Clinical research on TX and NX regimens in treatment of liver metastasis of breast cancer[J].Matern Child Health Care China,2014,29(34):5695-5697.(in Chinese)陈云兰,王羽丰,刘坤,等.TX与NX方案治疗乳腺癌肝转移的临床研究[J].中国妇幼保健,2014,29(34):5695-5697.

[15]HUA YY.Efficacy analysis of intervention for metastatic breast cancer[J].Anti-Tumor Pharm,2011,1(5):462-463,466.(in Chinese)华燕艳.乳腺癌肝转移介入治疗疗效分析[J].肿瘤药学,2011,1(5):462-463,466.

[16]GADALETA CD,RANIERI G.Trans-arterial chemoembolization as a therapy for liver tumours:new clinical developments and suggestions for combination with angiogenesis inhibitors[J].Crit Rev Oncol Hematol,2011,80(1):40-53.

施引文献

资源附件(0)

访问统计