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血清非对称性二甲基精氨酸在非酒精性脂肪性肝病大鼠模型肝脏炎症活动进程中的变化

丁洁 王亮 李娟 孔银 赵睿 何晶晶 李光明 王娟霞 张岭漪

柳正植, 高振月, 任庆, 霍丹丹, 杨海淼. 恩替卡韦片在中国健康人体中的生物等效性及安全性评价[J]. 临床肝胆病杂志, 2020, 36(12): 2695-2699. DOI: 10.3969/j.issn.1001-5256.2020.12.011.
引用本文: 柳正植, 高振月, 任庆, 霍丹丹, 杨海淼. 恩替卡韦片在中国健康人体中的生物等效性及安全性评价[J]. 临床肝胆病杂志, 2020, 36(12): 2695-2699. DOI: 10.3969/j.issn.1001-5256.2020.12.011.
LIU ZhengZhi, GAO ZhenYue, REN Qing, HUO DanDan, YANG HaiMiao. Bioequivalence and safety of entecavir tablets in healthy Chinese subjects[J]. J Clin Hepatol, 2020, 36(12): 2695-2699. DOI: 10.3969/j.issn.1001-5256.2020.12.011.
Citation: LIU ZhengZhi, GAO ZhenYue, REN Qing, HUO DanDan, YANG HaiMiao. Bioequivalence and safety of entecavir tablets in healthy Chinese subjects[J]. J Clin Hepatol, 2020, 36(12): 2695-2699. DOI: 10.3969/j.issn.1001-5256.2020.12.011.

血清非对称性二甲基精氨酸在非酒精性脂肪性肝病大鼠模型肝脏炎症活动进程中的变化

DOI: 10.3969/j.issn.1001-5256.2016.01.029
基金项目: 

2014年甘肃省自然科学基金项目(145RJZA147); 中央高校基本科研业务费专项资金(laujbky-2013-215); 

详细信息
  • 中图分类号: R575.5;R-332

Changes in serum asymmetric dimethylarginine levels in progression of liver inflammation in an experimental rat model of nonalcoholic fatty liver disease

Research funding: 

 

  • 摘要:

    目的利用非酒精性脂肪性肝病(NAFLD)大鼠模型观察血清非对称性二甲基精氨酸(ADMA)在NAFLD炎症进程的变化。方法肝组织标本及血清标本分别来自实验组高脂乳剂灌胃法成功构建的NAFLD模型(M组)及同期生理盐水灌胃替代构建的正常对照组(C组)。分别检测M组4、8、12周(M4、M8、M12)和C组12周(C12)大鼠血清ALT、ADMA水平及肝组织匀浆一氧化氮(NO)水平,同期评估各组肝脂肪炎症进程积分(NAS)。数据服从正态分布且方差齐,多组间比较应用单因素方差分析,进一步两两比较应用LSD-t法;服从正态分布且方差不齐,多组间比较应用Kruskal-Wallis H检验;相关性分析应用Pearson相关法。结果与C12组相比,M12组大鼠血清ALT、ADMA水平及肝组织匀浆NO水平显著升高,差异有统计学意义(P值分别为0.010、<0.001、<0.001)。血清ADMA与ALT水平无明显相关性(r=0.195,P=0.228),与肝组织匀浆NO水平、大鼠NAS呈正相关(r=0.631,P<0.001;r=0.782,P<0.001)。结论 NAFLD大...

     

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  • 收稿日期:  2015-06-18
  • 出版日期:  2016-01-20
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