Role of cell senescence in development and progression of nonalcoholic fatty liver disease
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摘要: 非酒精性脂肪性肝病(NAFLD)是一种非酒精原因所致的以肝细胞脂肪变性为主要特征的临床病理综合征,肝硬化及肝细胞癌是NAFLD的两个最为重要的肝病结局。细胞衰老是细胞脱离正常周期不可逆地丧失增殖能力后进入的一种相对稳定的状态,是细胞生命活动的一种客观规律。研究表明细胞衰老与NAFLD肝纤维化进程及肝细胞癌变的发生发展密切相关,为NAFLD相关肝硬化及肝细胞癌的防治提供了一个新的思路。Abstract: Nonalcoholic fatty liver disease( NAFLD) is a clinicopathological syndrome characterized by fatty degeneration of hepatocytes due to nonalcoholic reasons. Liver cirrhosis and hepatocellular carcinoma are two important outcomes of NAFLD. Cell senescence is a relatively stable state in which cells deviate from the normal cell cycle and experience an irreversible loss of proliferative capacity,which is an objective law in cell life. Research shows that cell senescence is closely associated with the progression of liver fibrosis and the development and progression of hepatocellular carcinoma in NAFLD,and provides a new perspective for the prevention and treatment of liver fibrosis and hepatocellular carcinoma.
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Key words:
- fatty liver /
- cell aging /
- liver cirrhosis /
- carcinoma,hepatocellular
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