Current status of research on microRNA associated with colorectal cancer liver metastasis
-
摘要: 肿瘤的转移是一个多步骤复杂的过程,肝转移是结直肠癌最常见的转移方式之一,对转移机制的理解和深入研究有助于寻求解决结直肠癌肝转移的方法,当前研究认为microRNA参与了肿瘤的转移与复发,通过对结直肠癌肝转移相关microRNA的研究,为疾病的发生发展、诊断治疗及预后等方面的研究提供了新的思路。归纳了结直肠癌肝转移相关microRNA的研究进展,回顾了microRNA的生物学功能以及分子机制,表明microRNA在肿瘤转移领域具有重要的意义,尤其在结直肠癌肝转移方面发挥着重要的作用。Abstract: Tumor metastasis is a complicated process with multiple steps,and liver metastasis is the most common metastatic mode of colorectal cancer. Deep understanding and study of metastatic mechanism helps to find solutions for colorectal cancer liver metastasis. Recent studies have shown that microRNA are involved in tumor metastasis and recurrence,and studies on microRNA associated with colorectal cancer liver metastasis can provide new thoughts for the development and progression,diagnosis and treatment,and prognosis of the disease.This article summarizes the research advances in microRNA associated with colorectal cancer liver metastasis and reviews the biological function and molecular mechanism of microRNA,which suggests that microRNA have a vital significance in the field of tumor metastasis,especially colorectal cancer liver metastasis.
-
Key words:
- colorectal neoplasms /
- neoplasm metastasis /
- microRNAs /
- review
-
[1]POURHOSEINGHOLI MA.Increased burden of colorectal cancer in Asia[J].World J Gastrointest Oncol,2012,4(4):68-70. [2]CHEN W,ZHENG R,BAADE PD,et al.Cancer statistics in China,2015[J].Ca A Cancer J Clin,2016,66(2):115-132. [3]CIDN EU.The challenge of metastatic colorectal cancer[J].Clin Med Insights Oncol,2010,4:55-60. [4]PARK JJ,LEE M.Increasing theα2,6 sialylation of glycoproteins may contribute to metastatic spread and therapeutic resistance in colorectal cancer[J].Gut Liver,2013,7(6):629-641. [5]SCHEPELER T,REINERT JT,OSTENFELD MS,et al.Diagnostic and prognostic microRNAs in stage II colon cancer[J].Cancer Res,2008,68(15):6416-6424. [6]ZHAO L,LIM SY,GORDON-WEEKS AN,et al.Recruitment of a myeloid cell subset(CD11b/Gr1 mid)via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis[J].Hepatology,2013,57(2):829-839. [7]NADAL C,MAUREL J,GASCON P,et al.Is there a genetic signature for liver metastasis in colorectal cancer?[J].World J Gastroenterol,2007,13(44):5832-5844. [8]OLSON P,LU J,ZHANG H,et al.MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer[J].Genes Dev,2009,23(18):2152-2165. [9]BARTEL DP.MicroRNAs:genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297. [10]ZHANG J,LI M.MicroRNA control of epithelial-mesenchymal transition and metastasis[J].Cancer Metastasis Rev,2012,31(3-4):653-662. [11]LUO X,BURWINKEL B,TAO S,et al.MicroRNA signatures:novel biomarker for colorectal cancer[J].Cancer Epidemiol Biomarkers Prev,2011,20(7):1272-1286. [12]BUSHATI N,COHEN SM.MicroRNA functions[J].Annu Rev of Cell Dev Biol,2007,23(1):175-205. [13]HURST DR,EDMONDS MD,WELCH DR.Metastamir-the field of metastasis-regulatory microRNA is spreading[J].Cancer Res,2009,69(19):7495-7498. [14]RAWLINGS-GOSS RA,CAMPBELL MC,TISHKOFF SA.Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers[J].Bmc Med Genomics,2014,7(1):1-14. [15]LU J,GETZ G,MISKA EA,et al.MicroRNA expression profiles classify human cancers.[J].Nature,2005,435(7043):834-838. [16]LI Z,YU X,SHEN J,et al.MicroRNA in intervertebral disc degeneration[J].Cell Prolif,2015,48(3):278-283. [17]WU DW,HSU NY,WANG YC,et al.c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT[J].Oncogene,2015,34(16):2072-2082. [18]YAN LX,HUANG XF,SHAO Q,et al.MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage,lymph node metastasis and patient poor prognosis[J].RNA,2008,14(11):2348-2360. [19]SHIBUYA H,IINUMA H,SHIMADA R,et al.Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer[J].Oncology,2011,79(3-4):313-320. [20]KULDA V,PESTA M,TOPOLCAN O,et al.Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases[J].Cancer Genet Cytogenet,2010,200(200):154-160. [21]ZHU L,CHEN H,ZHOU D,et al.MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility[J].Med Oncol,2012,29(2):1037-1043. [22]ZHAO H,XU Z,QIN H,et al.MiR-30b regulates migration and invasion of human colorectal cancer via SIX1[J].Biochem J,2014,460(1):117-125. [23]BRACKEN CP,GREGORY PA,KHEW-GOODALL Y,et al.The role of microRNAs in metastasis and epithelial-mesenchymal transition[J].Cell Mol Life Sci,2009,66(10):1682-1699. [24]POLYAK K,WEINBERG RA.Transitions between epithelial and mesenchymal states:acquisition of malignant and stem cell traits[J].Nat Rev Cancer,2009,9(4):265-273. [25]ZHANG G,ZHOU H,XIAO H,et al.MicroRNA-92a functions as an oncogene in colorectal cancer by targeting PTEN[J].Dig Dis Sci,2013,59(1):98-107. [26]HUR K,TOIYAMA Y,TAKAHASHI M,et al.MicroRNA-200c modulates epithelial-to-mesenchymal transition(EMT)in human colorectal cancer metastasis[J].Gut,2013,62(9):1315-1326. [27]JI D,CHEN Z,LI M,et al.MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1[J].Mol Cancer,2014,13(1):1-18. [28]LI Y,CHOI P,CASEY S,et al.MYC through miR-17-92,suppresses specific target genes to maintain survival,autonomous proliferation,and a neoplastic state[J].Cancer Cell,2014,26(2):262-272. [29]YANG F,MIAO L,MEI Y,et al.Retinoic acid-induced HOXA5expression is co-regulated by HuR and miR-130a[J].Cell Signal,2013,25(6):1476-1485. [30]QIN J,LUO M.MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK[J].Febs Lett,2014,588(1):99-104. [31]PNG KJ,HALBERG N,YOSHIDA M,et al.A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells[J].Nature,2012,481(7380):190-194. [32]MENENDEZ P,VILLAREJO P,PADILLA D,et al.Implications of the histological determination of microRNAs in the screening,diagnosis and prognosis of colorectal cancer[J].J Surg Oncol,2013,108(1):70-73. [33]WANG LG,GU J.Serum microRNA-29a is a promising novel marker for early detection of colorectal liver metastasis[J].Cancer Epidemiol,2012,36(1):e61-e67. [34]TOKARZ P,BLASIAK J.The role of MiRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment[J].Acta Biochim Pol,2012,59(4):467-474. [35]DING Q,CHANG CJ,XIE X,et al.APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis[J].J Clin Invest,2011,121(11):4526-4536. [36]HUR K,TOIYAMA Y,SCHETTER AJ,et al.Identification of a metastasis-specific MicroRNA signature in human colorectal cancer[J].J Natl Cancer Inst,2015,107(3).pii.dju492. [37]LOU X,QI X,ZHANG Y,et al.Decreased expression of microRNA-625 is associated with tumor metastasis and poor prognosis in patients with colorectal cancer[J].J Surg Oncol,2013,108(4):230-235. [38]IINO I,KIKUCHI H,MIYAZAKI S,et al.Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis[J].Cancer Sci,2013,104(5):624-630. [39]DONG Y,WU WK,WU CW,et al.MicroRNA dysregulation in colorectal cancer:a clinical perspective[J].Br J Cancer,2011,104(6):893-898. [40]HOGAN NM,JOYCE MR,KERIN MJ.MicroRNA expression in colorectal cancer[J].Cancer Biomark,2012,11(6):239-243. [41]LEWIS BP,BURGE CB,BARTEL DP.Conserved seed pairing,often flanked by adenosines,indicates that thousands of human genes are microRNA targets[J].Cell,2005,120(1):15-20.
本文二维码
计量
- 文章访问数: 2084
- HTML全文浏览量: 9
- PDF下载量: 444
- 被引次数: 0