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微生态制剂治疗肝硬化的Meta分析

孙元培 郭晓霞

杨明磊, 姚定康. 磁共振弹性成像在肝纤维化无创诊断中的应用[J]. 临床肝胆病杂志, 2016, 32(3): 588-592. DOI: 10.3969/j.issn.1001-5256.2016.03.042.
引用本文: 杨明磊, 姚定康. 磁共振弹性成像在肝纤维化无创诊断中的应用[J]. 临床肝胆病杂志, 2016, 32(3): 588-592. DOI: 10.3969/j.issn.1001-5256.2016.03.042.
Yang MingLei, Yao DingKang. Application of magnetic resonance elastography as a non-invasive technique for diagnosis of liver fibrosis[J]. J Clin Hepatol, 2016, 32(3): 588-592. DOI: 10.3969/j.issn.1001-5256.2016.03.042.
Citation: Yang MingLei, Yao DingKang. Application of magnetic resonance elastography as a non-invasive technique for diagnosis of liver fibrosis[J]. J Clin Hepatol, 2016, 32(3): 588-592. DOI: 10.3969/j.issn.1001-5256.2016.03.042.

微生态制剂治疗肝硬化的Meta分析

DOI: 10.3969/j.issn.1001-5256.2018.01.015
基金项目: 

山西省重点研发计划项目(201603D321042); 

详细信息
  • 中图分类号: R575.2

Clinical effect of probiotics in treatment of liver cirrhosis: a Meta-analysis

Research funding: 

 

  • 摘要:

    目的系统评价微生态制剂治疗肝硬化的有效性。方法计算机检索PubMed、Embase、Cochrane Library以及中国期刊全文数据库、维普、万方数据库,全面收集关于微生态制剂治疗肝硬化的随机对照试验,筛选后的文献应用Rev Man5.3软件进行Meta分析,其中二分类变量采用率差(RD)及其95%可信区间(95%CI)作为效应量;连续性变量若测量单位一致则采用加权均数差(WMD),测量单位不一致采用标准化均数差(SMD)及其95%CI进行评估。发表偏倚采用漏斗图进行分析。结果纳入符合标准的文献18篇,共1411例肝硬化患者,其中治疗组726例,对照组685例。与对照组相比,微生态制剂治疗可显著提高临床总体有效率(RD=0.28,95%CI:0.220.34,P<0.001);亦可以明显改善肝功能生化指标:ALT(SMD=-0.90,95%CI:-1.14-0.66,P<0.001)、TBil(WMD=-15.99,95%CI:-26.42-5.57,P<0.001)、Alb(SMD=0.66,95...

     

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