肝星状细胞通过TGFβ1-PI3K/AKT信号通路影响肝硬化-肝细胞癌癌前病变的研究进展

鞠迪; 李京涛; 韩曼; 魏海梁; 闫曙光; 李汨; 史晓燕; 常占杰

doi:10.3969/j.issn.1001-5256.2018.01.042

肝星状细胞通过TGFβ1-PI3K/AKT信号通路影响肝硬化-肝细胞癌癌前病变的研究进展

DOI: 10.3969/j.issn.1001-5256.2018.01.042

1. 陕西中医药大学
2. 陕西中医药大学附属医院

基金项目:

国家自然科学基金(81603612)；陕西省科技厅(2012SF2-11,2014K11-02-04-06,2016SF-234)；陕西省中医药管理局(15-JC009,JCPT037)；北京医学奖励基金会课题(YJHYXKYJJ-276)；陕西中医药大学自然科学创新基金项目(2017SZKY-037)；

详细信息

中图分类号: R575.2;R735.7
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出版历程
- 出版日期: 2018-01-20

Research advances in the influence of hepatic stellate cells on precancerous lesions of liver cirrhosis and hepatocellular carcinoma via the TGFβ1-PI3K/AKT signaling pathway

Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000, China

Research funding:

摘要

摘要:
肝硬化-肝细胞癌癌前病变的恶性转变导致肝癌的形成。肝星状细胞（HSC）通过TGFβ1-PI3K/AKT信号通路影响肝细胞癌癌前病变细胞产生、肝纤维化微环境的形成以及两者相互作用。了解肝硬化-肝细胞癌癌前病变的恶变机制与HSC和TGFβ1-PI3K/AKT信号通路的关系,将有助于深入了解肝细胞癌的发生机制。通过调控HSC或干预TGFβ1-PI3K/AKT信号通路可阻止甚至或逆转肝硬化向肝细胞癌的进展,为预防和干预肝细胞癌发生提供新的思路和治疗靶点。
- 肝硬化 /
- 癌,肝细胞 /
- 癌前状态 /
- 肝星状细胞 /
- 信号传导 /
- 综述
Abstract:
The malignant transformation of the precancerous lesions of liver cirrhosis and hepatocellular carcinoma ( HCC) leads to the formation of liver cancer. Hepatic stellate cells ( HSCs) play a role in the production of cells in precancerous lesions of HCC, the formation of hepatic fibrosis microenvironment, and the interaction between them via the TGFβ1-PI3 K/AKT signaling pathway. An understanding of the mechanism for the malignant transformation of the precancerous lesions of liver cirrhosis and HCC and the association between HSCs and the TGFβ1-PI3 K/AKT signaling pathway helps to investigate the pathogenesis of HCC. Regulation of HSCs or intervention of the TGFβ1-PI3 K/AKT signaling pathway can inhibit or reverse the progression of liver cirrhosis to HCC, which provides new thoughts and therapeutic targets for prevention and intervention of the development of HCC.
- liver cirrhosis /
- carcinoma, hepatocellular /
- precancerous conditions /
- hepatic stellate cell /
- signal transduction /
- review

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参考文献(30)

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