多种细胞在肝纤维化逆转中的作用

王林; 刘学恩; 庄辉

doi:10.3969/j.issn.1001-5256.2018.04.036

多种细胞在肝纤维化逆转中的作用

DOI: 10.3969/j.issn.1001-5256.2018.04.036

北京大学医学部病原生物学系和感染病中心

基金项目:

国家"十三五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2017ZX10302401-003-015)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2018-04-20

Cellular mechanisms in liver fibrosis regression

Department of Microbiology and Center of Infectious Diseases, Peking University Health Science Center

Research funding:

摘要

摘要:
在多种慢性肝损伤病因的作用下,肝星状细胞(HSC)等活化为肌成纤维细胞(MFB),迁移至损伤部位并大量分泌细胞外基质(ECM),ECM在肝内过度沉积,从而形成肝纤维化。当肝损伤病因被移除或经过有效治疗后,肝纤维化可发生逆转。介绍了多种细胞参与肝纤维化的逆转过程,MFB通过自身衰老、凋亡、失活,在肝纤维化逆转中发挥关键作用;巨噬细胞通过加快ECM降解和诱导MFB衰老等发挥抗肝纤维化功能;肝窦内皮细胞通过维持其正常表型阻断并逆转肝纤维化;自然杀伤细胞杀伤处于活化早期的HSC和衰老的MFB,参与肝纤维化逆转。
- 肝硬化 /
- 成纤维细胞 /
- 巨噬细胞 /
- 内皮细胞 /
- 杀伤细胞,天然 /
- 综述
Abstract:
With the action of various chronic factors for liver injury, hepatic stellate cells (HSCs) are activated and transformed to myofibroblasts (MFBs) and then migrate to the injured part and secrete a large amount of extracellular matrix (ECM) .Excessive deposition of ECM in the liver causes liver fibrosis.The elimination of factors for liver injury or effective treatment helps to achieve liver fibrosis regression.This article introduces the types of cells involved in liver fibrosis regression.MFBs play an important role liver fibrosis regression via senescence, apoptosis, and inactivation; macrophages exert an anti-fibrosis effect by accelerating ECM degradation and inducing MFB senescence; liver sinusoidal endothelial cells help to achieve liver fibrosis regression by maintaining its normal phenotype; natural killer cells are involved in liver fibrosis regression by killing the early activated HSCs and senescent MFBs.
- liver cirrhosis /
- fibroblasts /
- macrophages /
- endothelial cells /
- killer cells, natural /
- review

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参考文献(43)

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