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Clinical effect of pegylated interferon α-2a in treatment of previously untreated HBeAg-positive chronic hepatitis B patients and related predictive factors
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摘要: 目的探索聚乙二醇干扰素（PEG-IFNα-2a）初治的HBeAg阳性慢性乙型肝炎（CHB）患者的效果和疗效预测因素。方法回顾性研究2011年1月-2015年6月于安徽医科大学第二附属医院肝病科就诊的PEG-IFNα-2a初治的HBeAg阳性CHB患者111例。随访基线及治疗后12、24、48周时血清HBs Ag定量、HBeAg定量、HBV DNA定量、ALT水平。治疗48周时,111例患者中出现HBeAg血清学转换者35例（48周转换组）,未转换者76例（48周未转换组）。服从正态分布的计量资料组间比较采用独立样本t检验;非正态分布的计量资料组间比较采用Mann-Whitney U检验。计数资料组间比较采用χ2检验。受试者工作特征曲线（ROC曲线）评价各指标预测治疗终点疗效的效能,通过比较ROC曲线下面积（AUC）评估各指标预测价值。二分类logistic回归分析模型评估各自变量对HBeAg血清学转换影响大小。结果治疗前2组患者的HBeAg水平比较差异有统计学意义（t=-3.361,P<0.05）;治疗12周时HBs Ag定量（t=-3.225）、HBs Ag下降情况（Z=-2....Abstract: Objective To investigate the clinical effect of pegylated interferon α-2 a ( PEG-IFNα-2 a) in the treatment of previously untreated HBeAg-positive chronic hepatitis B ( CHB) patients and related predictive factors. Methods A retrospective analysis was performed for 111 previously untreated HBeAg-positive CHB patients who were treated with PEG-IFNα-2 a in Department of Hepatology in the Second Affiliated Hospital of Anhui Medical University from January 2011 to June 2015. The patients were followed up for serum HBs Ag quantitation, HBeAg quantitation, HBV DNA quantitation, and alanine aminotransferase ( ALT) level at baseline and at weeks 12, 24, and48 of treatment. At week 48 of treatment, of all 111 patients, 35 achieved HBeAg seroconversion ( 48-week seroconversion group) and 76 did not achieve such seroconversion ( 48-week non-seroconversion group) . The independent samples t-test was used for comparison of normally distributed continuous data between groups, and the Mann-Whitney U test was used for non-normally distributed continuous data between groups; the chi-square test was used for comparison of categorical data between groups. The receiver operating characteristic ( ROC) curve was used to evaluate the efficiency of related indices in predicting treatment outcomes, and the area under the ROC curve ( AUC) was compared to evaluate the predictive value of each index. The dichotomous logistic regression model was used to evaluate the influence of independent variables on HBeAg seroconversion. Results There was a significant difference in HBeAg level between the two groups before treatment ( t =-3. 361, P < 0. 05) . At week 12 of treatment, there were significant differences between the two groups in HBs Ag quantitation ( t =-3. 225, P < 0. 05) , reduction in HBs Ag ( Z =-2. 202, P < 0. 05) , HBeAg quantitation ( Z =-5. 025, P < 0. 05) , reduction in HBeAg ( Z =-3. 569, P < 0. 05) , HBV DNA quantitation ( Z =-3. 261, P < 0. 05) , and reduction in HBV DNA ( t = 2. 202, P < 0. 05) .At week 24 of treatment, there were significant differences between the two groups in HBs Ag quantitation ( t =-3. 222, P < 0. 05) , reduction in HBs Ag ( Z =-1. 860, P < 0. 05) , HBeAg quantitation ( Z =-5. 951, P < 0. 05) , reduction in HBeAg ( t = 5. 514, P < 0. 05) , HBV DNA quantitation ( Z =-2. 311, P < 0. 05) , and ALT level ( Z =-2. 234, P < 0. 05) . HBeAg quantitation at week 24 had a high predictive value ( AUC = 0. 88, P < 0. 001) , with a sensitivity of 94. 03%, a specificity of 64. 52%, a positive predictive value of85. 10%, and a negative predictive value of 83. 30% at a cut-off value of 0. 18 log10 S/CO. In addition, HBeAg quantitation at week 12 and reduction in HBeAg at week 24 had a good predictive value ( AUC = 0. 81 and 0. 80, respectively) . Baseline HBeAg < 2. 91 log10 S/CO ( odds ratio [OR]= 10. 086, 95% confidence interval [CI]: 1. 64-61. 93, P = 0. 013) , ALT < 1. 45 × upper limit of normal ( ULN) at week 24 ( OR = 5. 228, 95% CI: 1. 27-21. 45, P = 0. 022) , and reduction in HBeAg > 1. 5 log10 S/CO at week 24 ( OR = 5. 780, 95%CI: 1. 38-24. 25, P = 0. 016) were independent predictive factors for HBeAg seroconversion at week 48. Conclusion Baseline HBeAg level, HBs Ag/HBeAg/HBV DNA levels and reductions at week 12 of treatment, HBs Ag/HBeAg levels and reductions at week 24 of treatment, and HBV DNA and ALT levels at the same time points have a certain value in predicting HBeAg seroconversion at week 48.
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Key words:
- hepatitis B, chronic /
- polyethylene glycols /
- interferons /
- hepatitis B e antigens /
- treatment outcome
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本站查看6. 吴明杰. 聚乙二醇干扰素α-2b对慢性乙型肝炎的作用分析. 中国继续医学教育. 2019(12): 142-144 . 百度学术7. 张珊，王艺璇，孙静，朱琳，王凤水，邢卉春. 干扰素联合抗病毒治疗对提高核苷（酸）类药物经治慢性乙型肝炎患者表面抗原阴转率的影响. 中华实验和临床感染病杂志(电子版). 2019(04): 273-280 . 百度学术8. 郭志勇，贺文娟，裴军芳. 聚乙二醇干扰素α-2a注射液联合替诺福韦酯治疗e抗原阳性慢性乙型肝炎疗效分析. 中国药物与临床. 2019(22): 3944-3946 . 百度学术其他类型引用(4)
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