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射频消融联合系统化疗治疗不可切除或术后复发肝内胆管癌的效果和安全性

孙巍 丁晓燕 陈京龙 李文东 郭晓笛 申燕军 孙莎莎 滕颖 刘晓民 魏建莹

引用本文:
Citation:

射频消融联合系统化疗治疗不可切除或术后复发肝内胆管癌的效果和安全性

DOI: 10.3969/j.issn.1001-5256.2018.08.025
基金项目: 

首都临床特色应用研究与成果推广(Z161100000516141); 

详细信息
  • 中图分类号: R735.8

Clinical effect and safety of radiofrequency ablation combined with systemic chemotherapy in treatment of unresectable or postoperative recurrent intrahepatic cholangiocellular carcinoma

Research funding: 

 

  • 摘要: 目的回顾性分析经皮射频消融治疗(RFA)联合静脉化疗治疗不可切除或术后复发肝内胆管癌的效果及安全性。方法选取2011年1月-2016年12月首都医科大学附属北京地坛医院诊治的不可切除或术后复发肝内胆管癌患者。所有患者首先行RFA治疗。RFA治疗均在CT引导下完成。术后1周开始进行全身化疗,方案为吉西他滨联合顺铂(具体为吉西他滨1000 mg/m2第1、8天及顺铂25 mg/m2第1、8天,共6个周期)。主要观察指标为完全消融率、客观缓解率、至疾病进展时间、肿瘤局部进展率、生存时间和安全性。结果 24例患者中共包含45个病灶,均完成RFA治疗及化疗。客观缓解率为79.2%,术后1个月肿瘤完全消融率为86.7%(39/45)。术后随访1167个月,至随访结束肿瘤局部进展率为20.0%(9/45);中位至疾病进展时间为13.0个月;中位生存时间为28.6个月,1、2、3年生存率分别为87.3%、69.3%、32.6%。至随访结束主要副反应为血液学毒性及转氨酶升高,无手术严重并发症发生。结论 RFA联合系统化疗治疗不可切除或术后复发肝内胆管癌是一种安全可行的方案。

     

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  • 收稿日期:  2018-03-01
  • 出版日期:  2018-08-20
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