中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

翻译控制肿瘤蛋白的生物学功能及其在肝细胞癌发生发展中的作用

刘奇 刘薇 林智斌 窦科峰

引用本文:
Citation:

翻译控制肿瘤蛋白的生物学功能及其在肝细胞癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2018.08.046
基金项目: 

国家自然科学基金(81602435); 

详细信息
  • 中图分类号: R735.7

Biological function of translationally controlled tumor protein and its role in the development and progression of hepatocellular carcinoma

Research funding: 

 

  • 摘要: 翻译控制肿瘤蛋白(TCTP)广泛表达于绝大多数动植物细胞内,参与多种生理学活动。研究发现TCTP在肝癌组织中的表达量明显高于正常组织。介绍了TCTP的主要生物学功能,包括促进细胞生长和发育、调节细胞周期、抑制细胞凋亡、减轻细胞应激反应、调节炎症反应等。简述了TCTP在肝细胞癌(HCC)的发生发展中,除了改变细胞周期、抑制细胞凋亡以外,还可通过诱导细胞有丝分裂缺陷、诱导染色体不稳定性、介导炎症反应与肝纤维化,促进HCC的发生发展。认为TCTP可以作为HCC早期诊断的潜在指标,靶向降低TCTP表达水平有望成为一种新的HCC治疗方法。

     

  • [1]YENOFSKY R, CEREGHINI S, KROWCZYNSKA A, et al.Regulation of mRNA utilization in mouse erythroleukemia cells induced to differentiate by exposure to dimethyl sulfoxide[J].Mol Cell Biol, 1983, 3 (7) :1197-1203.
    [2]ULRICH B, BERND T.The translationally controlled tumour protein (TCTP) [J].Int J Biochem Cell Biol, 2004, 36 (3) :379-385.
    [3]ACUNZO J, BAYLOT V, SO A, et al.TCTP as therapeutic target in cancers[J].Cancer Treat Rev, 2014, 40 (6) :760-769.
    [4]CHITPATIMA ST, MAKRIDES S, BANDYOPADHYAY R, et al.Nucleotide sequence of a major messenger RNA for a 21 kilodalton polypeptide that is under translational control in mouse tumor cells[J].Nucleic Acids Res, 1988, 16 (5) :2350.
    [5]BOMMER UA, BOROVJAGIN A, GREAGG MA, et al.The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR[J].RNA, 2002, 8 (4) :478-496.
    [6]KUMAR R, MAURYA R, SARAN S.Identification of novel inhibitors of the translationally controlled tumor protein (TCTP) :Insights from molecular dynamics[J].Mol Biosyst, 2017, 13 (3) :510-524.
    [7]HINOJOSA-MOYA J, XOCONOSTLE-CAZARES B, PIEDRA-IBARRA E, et al.Phylogenetic and structural analysis of translationally controlled tumor proteins[J].J Mol Evol, 2008, 66 (5) :472-483.
    [8]CHEN SH, WU PS, CHOU CH, et al.A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue-or cell type-specific manner[J].Mol Bio Cell, 2007, 18 (7) :2525-2532.
    [9]GACHET Y, TOURNIER S, LEE M, et al.The growth-related, translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules during the cell cycle[J].J Cell Sci, 1999, 112 (8) :1257-1271.
    [10]YARM FR.Plk phosphorylation regulates the microtubule-stabilizing protein TCTP[J].Mol Cell Biol, 2002, 22 (17) :6209-6021.
    [11]LIU H, PENG HW, CHENG YS, et al.Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP[J].Mol Cell Biol, 2005, 25 (8) :3117-3126.
    [12]THEBAULT S, AGEZ M, CHI X, et al.TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-x L[J].Sci Rep, 2016, 6:19725.
    [13]SUSINI L, BESSE S, DUFLAUT D, et al.TCTP protects from apoptotic cell death by antagonizing bax function[J].Cell Death Differ, 2008, 15 (8) :1211-1220.
    [14]CHEN W, WANG H, TAO S, et al.Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival[J].Cell Cycle, 2013, 12 (14) :2321-2328.
    [15]STURZENBAUM S, KILLE P, MORGAN A.Identification of heavy metal induced changes in the expression patterns of the translationally controlled tumour protein (TCTP) in the earthworm Lumbricus rubellus1[J].Biochim Biophys Acta, 1998, 1398 (3) :294-304.
    [16]XU A, BELLAMY A, TAYLOR J.Expression of translationally controlled tumour protein is regulated by calcium at both the transcriptional and post-transcriptional level[J].Biochem J, 1999, 342 (3) :683-689.
    [17]GNANASEKAR M, DAKSHINAMOORTHY G, RAMASWAMY K.Translationally controlled tumor protein is a novel heat shock protein with chaperone-like activity[J].Biochem Biophys Res Commun, 2009, 386 (2) :333-337.
    [18]RAO KV, CHEN L, GNANASEKAR M, et al.Cloning and characterization of a calcium-binding, histamine-releasing protein from Schistosoma mansoni[J].J Bio Chem, 2002, 277 (34) :31207-31213.
    [19]CHOI S, MIN HJ, KIM M, et al.Proton pump inhibitors exert anti-allergic effects by reducing TCTP secretion[J].PLo S One, 2009, 4 (6) :e5732.
    [20]KIM M, CHUNG J, LEE C, et al.A peptide binding to dimerized translationally controlled tumor protein modulates allergic reactions[J].J Mol Med (Berl) , 2011, 89 (6) :603-610.
    [21]ZHANG G, LI R, ZHAO X, et al.Validation of the American Joint Committee on cancer eighth edition staging system in patients undergoing hepatectomy for hepatocellular carcinoma:A US populationbased study[J].J Surg Res, 2018, 222:55-68.
    [22]INTARAPRASONG P, SIRAMOLPIWAT S, VILAICHONE R.Advances in management of hepatocellular carcinoma[J].Asian Pac J Cancer Prev, 2016, 17 (8) :3697-3703.
    [23] JEMAL A, BRAY F, CENTER M, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61 (2) :69-90.
    [24]LI Z, ZHU JY.An interpretation of diagnosis, management, and treatment of hepatocellular carcinoma (V2017) [J].J Clin Hepatol, 2017, 33 (9) :1655-1657. (in Chinese) 李照, 朱继业.《原发性肝癌诊疗规范 (2017年版) 》解读[J].临床肝胆病杂志, 2017, 33 (9) :1655-1657.
    [25] ZHU WL, CHENG HX, HAN N, et al.Messenger RNA expression of translationally controlled tumor protein (TCTP) in liver regeneration and cancer[J].Anticancer Res, 2008, 28 (3A) :1575-1580.
    [26]CHAN TH, CHEN L, LIU M, et al.Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development[J].Hepatology, 2012, 55 (2) :491-505.
    [27]KENNEDY E, DYSART M, LIANGA N, et al.Redundant regulation of Cdk1 tyrosine dephosphorylation in saccharomyces cerevisiae[J].Genetics, 2016, 202 (3) :903-910.
    [28]LIANGA N, WILLIAMS EC, KENNEDY EK, et al.A Wee1checkpoint inhibits anaphase onset[J].J Cell Biol, 2013, 201 (6) :843-862.
    [29]Mc CLELLAND S.Role of chromosomal instability in cancer progression[J].Endocr Relat Cancer, 2017, 24 (9) :t23-t31.
    [30]CHANG SL, LAI HY, TUNG SY, et al.Dynamic large-scale chromosomal rearrangements fuel rapid adaptation in yeast populations[J].PLo S Genet, 2013, 9 (1) :e1003232.
    [31]ZHAO F, HU MD, CHEN P.Advances in the study of the effect of inflammatory factors on liver cancer[J].J World Latest Med Inf, 2017, 17 (14) :26-28. (in Chinese) 赵方, 胡明道, 陈鹏.炎症因子对肝癌影响的研究进展[J].世界最新医学信息文摘, 2017, 17 (14) :26-28.
    [32]LI XF, CHEN C, XIANG DM, et al.Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance[J].Hepatology, 2017, 66 (6) :1934-1951.
    [33]The national health and family planning commission of the People's Republic of China.Diagnosis, management, and treatment of hepatocellular carcinoma (V2017) [J].J Clin Hepatol, 2017, 33 (8) :1419-1431. (in Chinese) 中华人民共和国国家卫生和计划生育委员会.原发性肝癌诊疗规范 (2017年版) [J].临床肝胆病杂志, 2017, 33 (8) :1419-1431.
    [34]PARK J, HONG S, KIM J, et al.Proteinic marker for early diagnosis of liver cancer[P].United States Patent 8937165.2015-01-02.
    [35]HAO S, QIN Y, YIN S, et al.Serum translationally controlled tumor protein is involved in rat liver regeneration after hepatectomy[J].Hepatol Res, 2016, 46 (13) :1392-1401.
    [36]ZHANG F, MA Q, XU Z, et al.Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer[J].J Exp Clin Cancer Res, 2017, 36 (1) :68.
    [37]BOIA-FERREIRA M, BASILIO AB, HAMASAKI A, et al.TCTP as a therapeutic target in melanoma treatment[J].Brit J Cancer, 2017, 117 (5) :656-665.
    [38]CHUANG WL, LIN PY, LIN HC, et al.The apoptotic effect of ursolic acid on SK-Hep-1 cells is regulated by the PI3K/Akt, p38and JNK MAPK signaling pathways[J].Molecules, 2016, 21 (4) :460.
    [39]ZHU WL, CHENG HX, HAN N, et al.Messenger RNA expression of translationally controlled tumor protein (TCTP) in liver regeneration and cancer[J].Anticancer Res, 2008, 28 (3A) :1575-1580.
    [40]DU J, YANG P, KONG F, et al.Aberrant expression of translationally controlled tumor protein (TCTP) can lead to radioactive susceptibility and chemosensitivity in lung cancer cells[J].Oncotarget, 2017, 8 (60) :101922-101935.
    [41]XIAO B, CHEN D, LUO S, et al.Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/MMP9 signaling[J].Oncotarget, 2016, 7 (31) :50057-50073.
  • 加载中
计量
  • 文章访问数:  413
  • HTML全文浏览量:  16
  • PDF下载量:  103
  • 被引次数: 0
出版历程
  • 收稿日期:  2018-02-07
  • 出版日期:  2018-08-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回