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自噬与氧化应激在非酒精性脂肪性肝病发病机制中的关系

周帆 彭君伟 范伏岗 蒋元烨 曹勤

李甜甜, 孙静, 王权, 丁俊强, 王佳, 薛慧, 张弢, 段学章. 小肝癌立体定向放射治疗的效果及预后分析[J]. 临床肝胆病杂志, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
引用本文: 李甜甜, 孙静, 王权, 丁俊强, 王佳, 薛慧, 张弢, 段学章. 小肝癌立体定向放射治疗的效果及预后分析[J]. 临床肝胆病杂志, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
Li TianTian, Sun Jing, Wang Quan, Ding JunQiang, Wang Jia, Xue Hui, Zhang Tao, Duan XueZhang. Clinical effect of stereotactic body radiotherapy in treatment of patients with small hepatocellular carcinoma and related prognostic factors[J]. J Clin Hepatol, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.
Citation: Li TianTian, Sun Jing, Wang Quan, Ding JunQiang, Wang Jia, Xue Hui, Zhang Tao, Duan XueZhang. Clinical effect of stereotactic body radiotherapy in treatment of patients with small hepatocellular carcinoma and related prognostic factors[J]. J Clin Hepatol, 2018, 34(8): 1702-1706. DOI: 10.3969/j.issn.1001-5256.2018.08.022.

自噬与氧化应激在非酒精性脂肪性肝病发病机制中的关系

DOI: 10.3969/j.issn.1001-5256.2018.08.048
基金项目: 

国家自然科学基金(青年)项目(81703879); 上海中医药大学预算内项目(2016YSN60); 上海市普陀区中心医院专科规培院级课题(PTZP201605A); 上海中医药大学附属普陀医院人才培养项目(2016212B); 

详细信息
  • 中图分类号: R575.5

Interrelation between autophagy and oxidative stress in pathogenesis of nonalcoholic fatty liver

Research funding: 

 

  • 摘要: 非酒精性脂肪性肝病(NAFLD)是多种因素共同作用的结果,而以氧化应激为中心的"第二次打击"是NAFLD进展的关键因素。自噬作为近年来的研究热点,越来越多的证据显示自噬在肝细胞脂质代谢、炎症反应与肝纤维化中发挥重要作用,且与氧化应激有着密切关系。结合当前国内外最新研究成果分别从自噬与NAFLD的关系、氧化应激与NAFLD的关系分析自噬与氧化应激在NAFLD发病机制中的相互关系,指出自噬在NAFLD发病进程中调控氧化应激的分子机制可能成为今后的研究热点,若能够阻断或者激活自噬调控氧化应激的某个关键通路,或可为干预NAFLD提供新的手段。

     

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  • 收稿日期:  2018-03-23
  • 出版日期:  2018-08-20
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