p53凋亡刺激蛋白2的生物学功能及其在肝病中的作用

张译之; 时红波; 陈煜

doi:10.3969/j.issn.1001-5256.2018.11.039

p53凋亡刺激蛋白2的生物学功能及其在肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2018.11.039

1. 首都医科大学附属北京佑安医院人工肝中心
2. 北京市肝病研究所

基金项目:

北京市自然科学基金(7172102)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2018-11-20

Biological functions of apoptosis stimulating protein of p53 2 and its role in liver diseases

Research funding:

摘要

摘要: p53凋亡刺激蛋白2(ASPP2)是p53凋亡刺激蛋白家族成员,其能够特异性地与p53蛋白的核心区域结合,增强p53促进凋亡基因转录的能力。目前认为,ASPP2在调控细胞凋亡、自噬、增殖以及影响炎症、肿瘤的进展中发挥重要作用。总结了ASPP2的主要生物学功能以及在肝细胞癌、丙型肝炎及非酒精性脂肪性肝病中的研究进展。研究证明ASPP2能调控细胞的凋亡,并提示ASPP2可能成为多种疾病的潜在治疗靶点。
- 肝疾病 /
- 肿瘤抑制蛋白质p53 /
- 综述
Abstract: Apoptosis stimulating protein of p53 2 ( ASPP2) is a member of the apoptosis stimulating proteins of p53 and can specifically bind to the core region of p53 protein and enhance the ability of p53 to promote transcription of apoptotic genes. At present, it is believed that ASPP2 plays an important role in regulating cell apoptosis, autophagy, proliferation and affecting the progression of inflammation and tumors.This article summarizes the main biological functions of ASPP2 and the research advances in the role of ASPP2 in hepatocellular carcinoma, hepatitis C, and nonalcoholic fatty liver disease. Studies have shown that ASPP2 can regulate cell apoptosis and may be a potential therapeutic target for a variety of diseases.
- liver diseases /
- tumor suppressor protein p53 /
- review

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参考文献(39)

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