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空腹C肽联合FIB-4指数对2型糖尿病合并非酒精性脂肪性肝病患者肝纤维化进展的评估价值

任桂晶 韩琳 秦少游 王心刚 周长玉

杨新英, 康富标, 叶立红, 戴二黑, 孙殿兴. 慢性乙型肝炎及肝硬化患者血清高迁移率族蛋白B1水平变化及临床意义[J]. 临床肝胆病杂志, 2018, 34(9): 1901-1904. DOI: 10.3969/j.issn.1001-5256.2018.09.015.
引用本文: 杨新英, 康富标, 叶立红, 戴二黑, 孙殿兴. 慢性乙型肝炎及肝硬化患者血清高迁移率族蛋白B1水平变化及临床意义[J]. 临床肝胆病杂志, 2018, 34(9): 1901-1904. DOI: 10.3969/j.issn.1001-5256.2018.09.015.
Yang XinYing, Kang FuBiao, Ye LiHong, Dai ErHei, Sun DianXing. Level of high-mobility group box 1 in patients with chronic hepatitis B and liver cirrhosis and its clinical significance[J]. J Clin Hepatol, 2018, 34(9): 1901-1904. DOI: 10.3969/j.issn.1001-5256.2018.09.015.
Citation: Yang XinYing, Kang FuBiao, Ye LiHong, Dai ErHei, Sun DianXing. Level of high-mobility group box 1 in patients with chronic hepatitis B and liver cirrhosis and its clinical significance[J]. J Clin Hepatol, 2018, 34(9): 1901-1904. DOI: 10.3969/j.issn.1001-5256.2018.09.015.

空腹C肽联合FIB-4指数对2型糖尿病合并非酒精性脂肪性肝病患者肝纤维化进展的评估价值

DOI: 10.3969/j.issn.1001-5256.2018.12.015
详细信息
  • 中图分类号: R587.1;R575.5

Clinical significance of fasting C-peptide combined with fibrosis-4 index in assessing the progression of liver fibrosis in type 2 diabetic patients with nonalcoholic fatty liver disease

  • 摘要: 目的利用空腹C肽联合FIB-4指数评估2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者肝纤维化进展状况。方法选取2016年5月-2017年7月于吉林大学中日联谊医院体检中心进行体检并诊断为T2DM合并NAFLD的患者513例,根据FibroScan测得的肝脏组织硬度值(LSM),将患者分为非进展性肝纤维化组(466例)及进展性肝纤维化组(47例)。记录所有患者的年龄、腹围、血压、BMI、PLT计数、空腹血糖、空腹C肽、肝功能、血脂、尿酸、FIB-4指数,2组患者计量资料的比较,采用t检验或Mann-Whithey U检验,计数资料的比较采用χ2检验,用logistic回归方法筛选危险因素并构建联合诊断模型,采用受试者工作特征曲线对诊断效能进行评估。结果进展性肝纤维化组患者的年龄、AST水平、FIB-4指数、空腹C肽水平分别为51(49~55)岁、28. 9(25. 7~35. 1) U/L、0. 97(0. 75~1. 34)、(2. 64±0. 66) ng/ml,均高于非进展性肝纤维化组的50 (47~53)岁、27. 1(22. 2~32. 8) U/L、0. 85...

     

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