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Effect of probiotics in treatment of nonalcoholic fatty liver disease: A Meta-analysis
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摘要:
目的系统分析益生菌制剂对非酒精性脂肪性肝病（NAFLD）的治疗价值。方法检索2017年12月前在PubMed、The Cochrane Library、Embase、Medline、中国知网、万方及维普等数据库中公开发表的益生菌制剂治疗NAFLD的随机对照试验。对检索结果进行二次筛选、纳入研究风险偏移评估及信息提取后,采用RevMan 5. 3软件进行Meta分析。结果共纳入11项随机对照试验、599例NAFLD患者,结果显示:益生菌制剂可明显改善NAFLD患者的ALT（MD=-15. 23,95%CI:-19. 63～-10. 82,P <0. 000 01）、AST（MD=-17. 08,95%CI:-24. 23～-9. 92,P <0. 000 01）、GGT（MD=-20. 49,95%CI:-26. 23～-14. 74,P <0. 000 01）、TG（MD=-0. 12,95%CI:-0. 24～-0. 01,P=0. 04）、TC（MD=-0. 33,95%CI:-0. 56～-0. 11,P=0. 003）、HDL（MD=-0. 07,95%CI:...
Abstract:Objective To systematically analyze the value of probiotics in the treatment of nonalcoholic fatty liver disease (NAFLD) .Methods PubMed, The Cochrane Library, Embase, Medline, CNKI, VIP, and Wanfang Data were searched for randomized controlled trials (RCTs) on probiotics in the treatment on NAFLD published before December 2017. Secondary screening was performed for retrieval results, the risk of bias of the studies included was evaluated, and related data were extracted. Rev Man 5. 3 was used for the meta-analysis.Results A total of 11 RCTs with 599 NAFLD patients were included. The results showed that probiotics significantly improved the levels of alanine aminotransferase (mean difference [MD]=-15. 23, 95% confidence interval [CI]:-19. 63 to-10. 82, P < 0. 000 01) , aspartate aminotransferase (MD =-17. 08, 95% CI:-24. 23 to-9. 92, P < 0. 000 01) , gamma-glutamyl transpeptidase (MD =-20. 49, 95%CI:-26. 23 to-14. 74, P < 0. 000 01) , triglyceride (MD =-0. 12, 95% CI:-0. 24 to-0. 01, P = 0. 04) , total cholesterol (MD =-0. 33, 95% CI:-0. 56 to-0. 11, P = 0. 003) , high-density lipoprotein (MD =-0. 07, 95% CI:-0. 14 to-0. 01, P = 0. 03) , tumor necrosis factor-α (MD =-0. 38, 95% CI:-0. 52 to-0. 24, P < 0. 000 01) , and homeostasis model assessment of insulin resistance (MD =-0. 39, 95% CI:-0. 53 to-0. 24, P < 0. 000 01) . However, probiotics had no significant effect on body mass index (MD =-0. 73, 95% CI:-1. 91 to 0. 46, P = 0. 23) and low-density lipoprotein (MD =-0. 30, 95% CI:-0. 60 to 0. 01, P = 0. 06) .Conclusion Probiotics can significantly reduce the levels of liver aminotransferases, blood lipids, inflammatory factors, and insulin resistance in patients with NAFLD and thus exerts a certain therapeutic effect on NAFLD.
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Key words:
- non-alcoholic fatty liver disease /
- probiotics /
- treatment outcome /
- Meta analysis
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