Clinical diagnosis of alcoholic hepatitis
-
摘要: 根据酒精性肝炎(AH)和重症AH的概念、临床特征、预后等的明显差异,建议将AH明确区分为轻症AH和重症AH。住院的酒精性肝病(ALD)患者的疾病谱,肝硬化占绝大多数,同时轻症AH和重症AH共占比15%左右。重症AH包含酒精性肝衰竭;重症AH是临床诊断,而酒精性脂肪性肝炎是病理诊断。重症AH欧美国家的临床诊断标准趋于一致,而2018年中国指南与欧美国家不一致。Abstract: Based on the significant differences in definition, clinical features, and prognosis between alcoholic hepatitis ( AH) and severeAH, it is recommended to classify AH into mild and severe AH. As for the disease spectrum of hospitalized patients with alcoholic liver dis-ease, most patients have liver cirrhosis, and about 15% have mild or severe AH. Alcoholic liver failure belongs to the category of severeAH. Severe AH is a clinical diagnosis, while alcoholic steatohepatitis is a pathological diagnosis. The clinical diagnostic criteria for severeAH tend to be consistent in European and the United States of America, but the Chinese guideline released in 2018 is not consistent with theguidelines from western countries.
-
Key words:
- hepatitis, alcoholic /
- diagnosis
-
[1] National Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association;Fatty Liver Expert Committee, Chinese Medical Doctor Associ-ation. Guidelines of prevention and treatment for alcoholic liverdisease:A 2018 update[J]. J Clin Hepatol, 2018, 34 (5) :939-946. (in Chinese) 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会.酒精性肝病防治指南 (2018年更新版) [J].临床肝胆病杂志, 2018, 34 (5) :939-946. [2] CHANG BX, LI BS, HUANG A, et al. Changes of four com-mon non-infectious liver diseases for the hospitalized patientsin Beijing 302 hospital from 2002 to 2013[J]. Alcohol, 2016, 54:61-65. [3] HUANG A, CHANG BX, SUN Y, et al. Disease spectrum ofalcoholic liver disease in Beijing 302 Hospital from 2002 to2013:A large tertiary referral hospital experience from 7422patients[J]. Medicine (Baltimore) , 2017, 96 (7) :e6163. [4] CRABB DW, BATALLER R, CHALASANI NP, et al. Standarddefinitions and common data elements for clinical trials in pa-tients with alcoholic hepatitis:Recommendation from theNIAAA alcoholic hepatitis consortia[J]. Gastroenterology, 2016, 150 (4) :785-790. [5] SINGAL AK, BATALLER R, AHN J, et al. ACG clinical guide-line:Alcoholic liver disease[J]. Am J Gastroenterol, 2018, 113 (2) :175-194. [6] European Association for the Study of the Liver. EASL clinicalpractice guidelines:Management of alcohol-related liver dis-ease[J]. J Hepatol, 2018, 69 (1) :154-181. [7] Liver Failure and Artificial Liver Group, Chinese Society of In-fectious Diseases, Chinese Medical Association; Severe LiverDiseases and Artificial Liver Group, Chinese Society of Hepa-tology, Chinese Medical Association. Guidelines for diagnosisand treatment liver failure[J]. Chin J Clin Infect Dis, 2012, 5 (6) :321-327. (in Chinese) 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南 (2012年版) [J].中华临床感染病杂志, 2012, 5 (6) :321-327.
本文二维码
计量
- 文章访问数: 1545
- HTML全文浏览量: 45
- PDF下载量: 409
- 被引次数: 0